Fetoplacental Discrepancy with Normal Karyotype in Amniotic Fluid and Two Different Cell Lines in Placenta
Joint Authors
Velagaleti, Gopalrao V. N.
Williamson, Eric
Ortega, Veronica
Mendiola, Christina
Higby, Kenneth
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-13
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
We present a case of fetoplacental discrepancy in a second-trimester fetus with normal karyotype in amniotic fluid and two different Robertsonian translocations in placenta.
A 41-year-old woman of Middle-Eastern origin, gravida 2, para 1, underwent amniocentesis at 16-week gestation because of advanced maternal age.
Amniotic fluid karyotype showed a normal 46,XX karyotype with a homozygous inv(9).
Parental chromosome analysis showed both parents to be carriers of inv(9) and the parents are not consanguineous.
Fetal ultrasound was normal.
The mother presented to the clinic 4 weeks later with intrauterine fetal demise.
Chromosome analysis from the placenta showed two different cell lines: a balanced (15;21) Roberstonian translocation in 11 cells and an unbalanced (21;21) Robertsonian translocation in 9 cells.
The karyotype was interpreted as mos 45,XX,inv(9)(p11q13)x2,der(15;21)(q10;q10)[11]/46,XX,inv(9)(p11q13)x2,+21,der(21;21)(q10;q10).
Mother was a carrier for the Cystic Fibrosis (delta F508), Factor V Leiden mutations, HbD-Los Angeles and HbQ-India variants.
She also had a sibling with term stillbirth.
Her husband’s history was unremarkable.
Our case appears to be another example of confined placental mosaicism (CPM) with normal fetal karyotype.
However, we could not confirm the possibility that CPM contributed to the IUFD in our case given the complex medical history of the mother.
American Psychological Association (APA)
Ortega, Veronica& Mendiola, Christina& Williamson, Eric& Higby, Kenneth& Velagaleti, Gopalrao V. N.. 2013. Fetoplacental Discrepancy with Normal Karyotype in Amniotic Fluid and Two Different Cell Lines in Placenta. Case Reports in Genetics،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-510883
Modern Language Association (MLA)
Ortega, Veronica…[et al.]. Fetoplacental Discrepancy with Normal Karyotype in Amniotic Fluid and Two Different Cell Lines in Placenta. Case Reports in Genetics No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-510883
American Medical Association (AMA)
Ortega, Veronica& Mendiola, Christina& Williamson, Eric& Higby, Kenneth& Velagaleti, Gopalrao V. N.. Fetoplacental Discrepancy with Normal Karyotype in Amniotic Fluid and Two Different Cell Lines in Placenta. Case Reports in Genetics. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-510883
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510883