![](/images/graphics-bg.png)
Assessment of Mycobacterium bovis Deleted in p27-p55 Virulence Operon as Candidate Vaccine against Tuberculosis in Animal Models
Joint Authors
Cataldi, Angel Adrián
Williams, Ann
Blanco, Federico Carlos
García, Elizabeth
Garbaccio, Sergio
Bigi, Fabiana
Clark, Simon
Bianco, María Verónica
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-21
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
A Mycobacterium bovis knockout in p27-p55 operon was tested as an antituberculosis experimental vaccine in animal models.
The mutant MbΔp27-p55 was significantly more attenuated in nude mice than its parental strain but more virulent than BCG Pasteur.
Challenge experiments in mice and guinea pigs using M.
bovis or M.
tuberculosis strains showed similar protection conferred by MbΔp27-p55 mutant than BCG in terms of pathology and bacterial loads in spleen but lower protection than BCG in lungs.
When tested in cattle, MbΔp27-p55 did not induce IL-2 expression and induced a very low production of IFNγ, suggesting that the lack of P27/P55 reduces the capacity of M.
bovis of triggering an adequate Th1 response.
American Psychological Association (APA)
Bianco, María Verónica& Clark, Simon& Blanco, Federico Carlos& Garbaccio, Sergio& García, Elizabeth& Cataldi, Angel Adrián…[et al.]. 2014. Assessment of Mycobacterium bovis Deleted in p27-p55 Virulence Operon as Candidate Vaccine against Tuberculosis in Animal Models. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-510913
Modern Language Association (MLA)
Bianco, María Verónica…[et al.]. Assessment of Mycobacterium bovis Deleted in p27-p55 Virulence Operon as Candidate Vaccine against Tuberculosis in Animal Models. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-510913
American Medical Association (AMA)
Bianco, María Verónica& Clark, Simon& Blanco, Federico Carlos& Garbaccio, Sergio& García, Elizabeth& Cataldi, Angel Adrián…[et al.]. Assessment of Mycobacterium bovis Deleted in p27-p55 Virulence Operon as Candidate Vaccine against Tuberculosis in Animal Models. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-510913
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510913