Anti-Obesity and Anti-Diabetic Effects of Acacia Polyphenol in Obese Diabetic KKAy Mice Fed High-Fat Diet
Joint Authors
Ito, Kiyomi
Ikarashi, Nobutomo
Toda, Takahiro
Okaniwa, Takehiro
Sugiyama, Kiyoshi
Ochiai, Wataru
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-14
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Acacia polyphenol (AP) extracted from the bark of the black wattle tree (Acacia meansii) is rich in unique catechin-like flavan-3-ols, such as robinetinidol and fisetinidol.
The present study investigated the anti-obesity/anti-diabetic effects of AP using obese diabetic KKAy mice.
KKAy mice received either normal diet, high-fat diet or high-fat diet with additional AP for 7 weeks.
After the end of administration, body weight, plasma glucose and insulin were measured.
Furthermore, mRNA and protein expression of obesity/diabetic suppression-related genes were measured in skeletal muscle, liver and white adipose tissue.
As a result, compared to the high-fat diet group, increases in body weight, plasma glucose and insulin were significantly suppressed for AP groups.
Furthermore, compared to the high-fat diet group, mRNA expression of energy expenditure-related genes (PPARα, PPARδ, CPT1, ACO and UCP3) was significantly higher for AP groups in skeletal muscle.
Protein expressions of CPT1, ACO and UCP3 for AP groups were also significantly higher when compared to the high-fat diet group.
Moreover, AP lowered the expression of fat acid synthesis-related genes (SREBP-1c, ACC and FAS) in the liver.
AP also increased mRNA expression of adiponectin and decreased expression of TNF-α in white adipose tissue.
In conclusion, the anti-obesity actions of AP are considered attributable to increased expression of energy expenditure-related genes in skeletal muscle, and decreased fatty acid synthesis and fat intake in the liver.
These results suggest that AP is expected to be a useful plant extract for alleviating metabolic syndrome.
American Psychological Association (APA)
Ikarashi, Nobutomo& Toda, Takahiro& Okaniwa, Takehiro& Ito, Kiyomi& Ochiai, Wataru& Sugiyama, Kiyoshi. 2011. Anti-Obesity and Anti-Diabetic Effects of Acacia Polyphenol in Obese Diabetic KKAy Mice Fed High-Fat Diet. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-510915
Modern Language Association (MLA)
Ikarashi, Nobutomo…[et al.]. Anti-Obesity and Anti-Diabetic Effects of Acacia Polyphenol in Obese Diabetic KKAy Mice Fed High-Fat Diet. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-510915
American Medical Association (AMA)
Ikarashi, Nobutomo& Toda, Takahiro& Okaniwa, Takehiro& Ito, Kiyomi& Ochiai, Wataru& Sugiyama, Kiyoshi. Anti-Obesity and Anti-Diabetic Effects of Acacia Polyphenol in Obese Diabetic KKAy Mice Fed High-Fat Diet. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-510915
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510915