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Colonic Diffuse Large B-Cell Lymphoma in a Liver Transplant Patient with Historically Very Low Tacrolimus Levels
Joint Authors
Van Thiel, David Hoffman
Lamzabi, Ihab
Jakate, Shriram
Bartels, Anne K.
Moore, Christopher M.
Source
Case Reports in Transplantation
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-29
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Posttransplant lymphoproliferative disorders (PTLDs) comprise a wide spectrum of hematologic malignancies that are found increasingly in orthotopic liver transplant (OLT) patients given the rising frequency of these surgeries and their long-term success.
PTLDs are highly correlated with both the Epstein-Barr virus (EBV) infection and the degree of immunosuppression involved.
Herein is reported a case of a 53-year-old male with successfully treated hepatitis C virus genotype 4 and hepatocellular carcinoma who underwent OLT and developed symptoms of weakness and poor appetite 4 years later while on tacrolimus 3 mg b.i.d.
with historically very low plasma levels.
He was found to be anemic and colonoscopy revealed a 4.5 cm cecal diffuse large B-cell lymphoma (DLBCL).
Further workup revealed mesenteric lymph node enlargement consistent and nodal DLBCL dissemination.
He was treated with cyclophosphamide-hydroxyldaunorubicin-oncovin-prednisone-rituximab (CHOP-R) chemotherapy and his tacrolimus dose was lowered.
Additionally, he manifested PTLD-associated cryoglobulinemia leading to acute kidney injury.
After a prolonged hospitalization he was discharged with close followup.
American Psychological Association (APA)
Moore, Christopher M.& Lamzabi, Ihab& Bartels, Anne K.& Jakate, Shriram& Van Thiel, David Hoffman. 2012. Colonic Diffuse Large B-Cell Lymphoma in a Liver Transplant Patient with Historically Very Low Tacrolimus Levels. Case Reports in Transplantation،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-510940
Modern Language Association (MLA)
Moore, Christopher M.…[et al.]. Colonic Diffuse Large B-Cell Lymphoma in a Liver Transplant Patient with Historically Very Low Tacrolimus Levels. Case Reports in Transplantation No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-510940
American Medical Association (AMA)
Moore, Christopher M.& Lamzabi, Ihab& Bartels, Anne K.& Jakate, Shriram& Van Thiel, David Hoffman. Colonic Diffuse Large B-Cell Lymphoma in a Liver Transplant Patient with Historically Very Low Tacrolimus Levels. Case Reports in Transplantation. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-510940
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510940