Neuroblastoma in the Elderly and SIADH : Case Report and Review of the Literature
Joint Authors
Gianotti, Laura
Terzi, Alberto
Cassibba, Sara
Pellegrino, Micaela
Borretta, Giorgio
Brizio, Rodolfo
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-23
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objective.
To report the rare case of a thymic neuroblastoma, in an elderly woman with SIADH at presentation.
Methods.
Clinical and biochemical data of the patient are presented and the pertinent literature is reviewed.
Results.
a 79-year-old woman was admitted into our department with worsening asthenia, severe hyponatremia (114.8 mEq/L), low plasma osmolarity (253 mEq/L), and inappropriate urinary sodium concentration (151 mEq/L).
CT scan showed an a large solid inhomogeneous mass in the anterior mediastinum.
18F-FDG-PET/CT showed uptake in the mass.
On continuous 3% hypertonic saline infusion, sodium gradually increased without achieving normal values.
The patient underwent surgery, followed by full normalization of sodium levels.
Tumor cells were positive for neuroendocrine markers.
Thymic neuroblastoma with SIADH was diagnosed.
Conclusions.
Neuroblastoma is an extremely rare tumor in the elderly.
Contrary to children and younger adults, neuroblastoma in older adults is typically localized in the anterior mediastinum and is often associated with SIADH.
Moreover, it has mainly local aggressiveness in this age group, without metastatic spread; thus radical surgery achieves cure in most cases.
American Psychological Association (APA)
Pellegrino, Micaela& Gianotti, Laura& Cassibba, Sara& Brizio, Rodolfo& Terzi, Alberto& Borretta, Giorgio. 2012. Neuroblastoma in the Elderly and SIADH : Case Report and Review of the Literature. Case Reports in Medicine،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-510973
Modern Language Association (MLA)
Pellegrino, Micaela…[et al.]. Neuroblastoma in the Elderly and SIADH : Case Report and Review of the Literature. Case Reports in Medicine No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-510973
American Medical Association (AMA)
Pellegrino, Micaela& Gianotti, Laura& Cassibba, Sara& Brizio, Rodolfo& Terzi, Alberto& Borretta, Giorgio. Neuroblastoma in the Elderly and SIADH : Case Report and Review of the Literature. Case Reports in Medicine. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-510973
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510973