An Unusual Presentation of Liver Failure in a Patient with Primary Gastrointestinal Hodgkin's Lymphoma
Joint Authors
Malik, Jeffrey T.
Yang, David T.
Rocque, Gabrielle B.
Chang, Julie E.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-11-25
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Introduction.
Hodgkin's lymphoma (HL) presenting either with primary bowel involvement or with cholestasis is unusual.
The combination of primary gastrointestinal HL presenting with cholestasis and ductopenia has not been previously described.
Case Report.
We present a case of primary gastrointestinal HL with evidence of liver involvement, but also with prominent ductopenia on liver biopsy and associated intrahepatic cholestasis.
A 50-year-old man with a history of Crohn's disease presented with a bowel obstruction, for which he underwent a small bowel resection.
Histology revealed HL.
His course was complicated by cholestatic liver failure.
A subsequent liver biopsy revealed both focal involvement by lymphoma and ductopenia, resembling vanishing bile duct syndrome (VBDS).
He was treated with chemotherapy with improvement in his cholestasis, but he eventually succumbed due to further complications of his disease and treatment toxicities.
Conclusion.
This case of primary gastrointestinal HL associated with ductopenia does not meet classic criteria for VBDS, but the clinical presentation and pathology are suggestive of a VBDS-like paraneoplastic process.
Therapies for HL in the setting of cholestatic liver failure require special consideration, but some reports of durable remissions and recovery of liver function have been reported.
American Psychological Association (APA)
Rocque, Gabrielle B.& Malik, Jeffrey T.& Yang, David T.& Chang, Julie E.. 2010. An Unusual Presentation of Liver Failure in a Patient with Primary Gastrointestinal Hodgkin's Lymphoma. Lymphoma،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-510998
Modern Language Association (MLA)
Rocque, Gabrielle B.…[et al.]. An Unusual Presentation of Liver Failure in a Patient with Primary Gastrointestinal Hodgkin's Lymphoma. Lymphoma No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-510998
American Medical Association (AMA)
Rocque, Gabrielle B.& Malik, Jeffrey T.& Yang, David T.& Chang, Julie E.. An Unusual Presentation of Liver Failure in a Patient with Primary Gastrointestinal Hodgkin's Lymphoma. Lymphoma. 2010. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-510998
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510998