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Matrix Metalloproteinases in Neuropathic Pain and Migraine : Friends, Enemies, and Therapeutic Targets
Joint Authors
Avramut, Mihaela
Lakhan, Shaheen E.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Matrix metalloproteinases (MMPs) constitute a family of zinc-dependent endopeptidases that mediate extracellular matrix turnover and associated processes, such as cell survival, growth, and differentiation.
This paper discusses important functions of MMP in the normal and injured nervous system, focusing on the role played by these proteases in neurological pain syndromes, most prominently in neuropathic pain and migraine headaches.
In the past decade, metalloproteinases emerged as key modulators of neuropathic pain, with MMP-9 acting as an initiator of the neuropathic cascade.
Increased MMP activity was detected in migraine patients, independent of aura, in tight association with metabolic derangements.
The therapeutic implications of MMP inhibition are considered in the context of neurogenic pain regulation.
American Psychological Association (APA)
Lakhan, Shaheen E.& Avramut, Mihaela. 2012. Matrix Metalloproteinases in Neuropathic Pain and Migraine : Friends, Enemies, and Therapeutic Targets. Pain Research and Treatment،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-511002
Modern Language Association (MLA)
Lakhan, Shaheen E.& Avramut, Mihaela. Matrix Metalloproteinases in Neuropathic Pain and Migraine : Friends, Enemies, and Therapeutic Targets. Pain Research and Treatment No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-511002
American Medical Association (AMA)
Lakhan, Shaheen E.& Avramut, Mihaela. Matrix Metalloproteinases in Neuropathic Pain and Migraine : Friends, Enemies, and Therapeutic Targets. Pain Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-511002
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511002