The Role of Adipose Tissue in Insulin Resistance in Women of African Ancestry
Joint Authors
Evans, Juliet
Ellman, Nicole
Victor, Hendriena
Keswell, Dheshnie
Hume, David John
Levitt, Naomi S.
Kotze, Liske
Tootla, Mehreen
Goedecke, Julia H.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Women of African ancestry, particularly those living in industrialized countries, experience a disproportionately higher prevalence of type 2 diabetes (T2D) compared to their white counterparts.
Similarly, obesity and insulin resistance, which are major risk factors for T2D, are greater in black compared to white women.
The exact mechanisms underlying these phenomena are not known.
This paper will focus on the role of adipose tissue biology.
Firstly, the characteristic body fat distribution of women of African ancestry will be discussed, followed by the depot-specific associations with insulin resistance.
Factors involved in adipose tissue biology and their relation to insulin sensitivity will then be explored, including the role of sex hormones, glucocorticoid metabolism, lipolysis and adipogenesis, and their consequent effects on adipose tissue hypoxia, oxidative stress, and inflammation.
Finally the role of ectopic fat deposition will be discussed.
The paper proposes directions for future research, in particular highlighting the need for longitudinal and/or intervention studies to better understand the mechanisms underlying the high prevalence of insulin resistance and T2D in women of African ancestry.
American Psychological Association (APA)
Goedecke, Julia H.& Levitt, Naomi S.& Evans, Juliet& Ellman, Nicole& Hume, David John& Kotze, Liske…[et al.]. 2013. The Role of Adipose Tissue in Insulin Resistance in Women of African Ancestry. Journal of Obesity،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-511004
Modern Language Association (MLA)
Goedecke, Julia H.…[et al.]. The Role of Adipose Tissue in Insulin Resistance in Women of African Ancestry. Journal of Obesity No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-511004
American Medical Association (AMA)
Goedecke, Julia H.& Levitt, Naomi S.& Evans, Juliet& Ellman, Nicole& Hume, David John& Kotze, Liske…[et al.]. The Role of Adipose Tissue in Insulin Resistance in Women of African Ancestry. Journal of Obesity. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-511004
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511004