mTOR Pathway and mTOR Inhibitors in Head and Neck Cancer
Joint Authors
Li, John Zeng Hong
Wong, Thian-Sze
Gao, Wei
Ho, Wai Kuen
Chan, Jimmy Yu-Wai
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Head and neck cancer is the sixth most common type of Cancer worldwide.
Since conventional treatment regimens are nonselective and are associated with systemic toxicities, intense investigations focus on molecular targeted therapy with high selectivity and low adverse effects.
mTOR signaling pathway has been found to be activated in head and neck cancer, making it attractive for targeted therapy.
In addition, expression levels of mTOR and downstream targets eIF4E, 4EBP1, S6K1, and S6 are potential diagnostic and prognostic biomarkers for head and neck cancer.
mTOR inhibitors, such as rapamycin and its derivatives temsirolimus and everolimus, exhibit inhibitory effects on head and neck cancer in both in vitro cell line model and in vivo xenograft model.
A large number of clinical trials have been initiated to evaluate the therapeutic effects of mTOR inhibitors on patients with head and neck cancer.
mTOR inhibitor has potential as a single therapeutic agent or in combination with radiation, chemotherapeutic agents, or other targeted therapeutic agents to obtain synergistic repression on head and neck cancer.
American Psychological Association (APA)
Gao, Wei& Li, John Zeng Hong& Chan, Jimmy Yu-Wai& Ho, Wai Kuen& Wong, Thian-Sze. 2012. mTOR Pathway and mTOR Inhibitors in Head and Neck Cancer. ISRN Otolaryngology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-511020
Modern Language Association (MLA)
Gao, Wei…[et al.]. mTOR Pathway and mTOR Inhibitors in Head and Neck Cancer. ISRN Otolaryngology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-511020
American Medical Association (AMA)
Gao, Wei& Li, John Zeng Hong& Chan, Jimmy Yu-Wai& Ho, Wai Kuen& Wong, Thian-Sze. mTOR Pathway and mTOR Inhibitors in Head and Neck Cancer. ISRN Otolaryngology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-511020
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511020