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A Retrospectively Diagnosed Case of IgG4-Related Tubulointerstitial Nephritis Showing Good Renal Outcome and Pathological Progress
Joint Authors
Nakazawa, Raima
Wu, Qiong
Endoh, Masayuki
Tanaka, Hisae
Fukagawa, Masafumi
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
A 74-year-old man was hospitalized for diabetic nephropathy evaluation and assessment of the effect of treatment on his tubulointerstitial nephritis (TIN).
When he was 62 years old, he developed polyarthralgia and had superficial lymph node swelling, mildly increased serum creatinine concentration, hypergammaglobulinemia, hypocomplementemia, high serum IL-2R level, and positive titer of antinuclear antibody.
Several tissues were biopsied.
Mild chronic sialadenitis and reactive lymphadenitis were identified.
Renal specimen showed mild glomerular ischemia, extensive storiform fibrosis, and abundant infiltrating monocytes and plasma cells.
He was treated with oral prednisolone and cyclophosphamide.
After the treatment, most of his clinical parameters quickly returned to within the reference range.
However, he developed diabetes mellitus soon after steroid therapy.
At the time of rebiopsy, a high level of serum IgG4 was detected.
The second renal biopsy showed diabetic nephropathy without any tubulointerstitial damage.
The first biopsied tissues were retrospectively investigated.
Large numbers of IgG4-positive plasma cells were detected in the kidneys and lymph nodes.
A retrospective diagnosis of IgG4-related TIN with lymph node involvement was made.
In conclusion, this paper describes a retrospectively diagnosed case of IgG4-related TIN with lymph node involvement, showing good clinical and pathological prognosis.
American Psychological Association (APA)
Wu, Qiong& Nakazawa, Raima& Tanaka, Hisae& Endoh, Masayuki& Fukagawa, Masafumi. 2013. A Retrospectively Diagnosed Case of IgG4-Related Tubulointerstitial Nephritis Showing Good Renal Outcome and Pathological Progress. Case Reports in Nephrology،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-511038
Modern Language Association (MLA)
Wu, Qiong…[et al.]. A Retrospectively Diagnosed Case of IgG4-Related Tubulointerstitial Nephritis Showing Good Renal Outcome and Pathological Progress. Case Reports in Nephrology No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-511038
American Medical Association (AMA)
Wu, Qiong& Nakazawa, Raima& Tanaka, Hisae& Endoh, Masayuki& Fukagawa, Masafumi. A Retrospectively Diagnosed Case of IgG4-Related Tubulointerstitial Nephritis Showing Good Renal Outcome and Pathological Progress. Case Reports in Nephrology. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-511038
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511038