![](/images/graphics-bg.png)
Erythropoietin in Brain Development and Beyond
Joint Authors
Li, Xiaoxia
Noguchi, Constance Tom
Wang, Li
Rogers, Heather
Alnaeeli, Mawadda
Piknova, Barbora
Source
Anatomy Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-26
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Erythropoietin is known as the requisite cytokine for red blood cell production.
Its receptor, expressed at a high level on erythroid progenitor/precursor cells, is also found on endothelial, neural, and other cell types.
Erythropoietin and erythropoietin receptor expression in the developing and adult brain suggest their possible involvement in neurodevelopment and neuroprotection.
During ischemic stress, erythropoietin, which is hypoxia inducible, can contribute to brain homeostasis by increasing red blood cell production to increase the blood oxygen carrying capacity, stimulate nitric oxide production to modulate blood flow and contribute to the neurovascular response, or act directly on neural cells to provide neuroprotection as demonstrated in culture and animal models.
Clinical studies of erythropoietin treatment in stroke and other diseases provide insight on safety and potential adverse effects and underscore the potential pleiotropic activity of erythropoietin.
Herein, we summarize the roles of EPO and its receptor in the developing and adult brain during health and disease, providing first a brief overview of the well-established EPO biology and signaling, its hypoxic regulation, and role in erythropoiesis.
American Psychological Association (APA)
Alnaeeli, Mawadda& Wang, Li& Piknova, Barbora& Rogers, Heather& Li, Xiaoxia& Noguchi, Constance Tom. 2012. Erythropoietin in Brain Development and Beyond. Anatomy Research International،Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-511040
Modern Language Association (MLA)
Alnaeeli, Mawadda…[et al.]. Erythropoietin in Brain Development and Beyond. Anatomy Research International No. 2012 (2012), pp.1-15.
https://search.emarefa.net/detail/BIM-511040
American Medical Association (AMA)
Alnaeeli, Mawadda& Wang, Li& Piknova, Barbora& Rogers, Heather& Li, Xiaoxia& Noguchi, Constance Tom. Erythropoietin in Brain Development and Beyond. Anatomy Research International. 2012. Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-511040
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511040