Susceptibility to Dental Caries and the Salivary Proline-Rich Proteins
Author
Source
International Journal of Dentistry
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-29
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Early childhood caries affects 28% of children aged 2–6 in the US and is not decreasing.
There is a well-recognized need to identify susceptible children at birth.
Caries-free adults neutralize bacterial acids in dental biofilms better than adults with severe caries.
Saliva contains acidic and basic proline-rich proteins (PRPs) which attach to oral streptococci.
The PRPs are encoded within a small region of chromosome 12.
An acidic PRP allele (Db) protects Caucasian children from caries but is more common in African Americans.
Some basic PRP allelic phenotypes have a three-fold greater frequency in caries-free adults than in those with severe caries.
Early childhood caries may associate with an absence of certain basic PRP alleles which bind oral streptococci, neutralize biofilm acids, and are in linkage disequilibrium with Db in Caucasians.
The encoding of basic PRP alleles is updated and a new technology for genotyping them is described.
American Psychological Association (APA)
Levine, Martin. 2011. Susceptibility to Dental Caries and the Salivary Proline-Rich Proteins. International Journal of Dentistry،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-511050
Modern Language Association (MLA)
Levine, Martin. Susceptibility to Dental Caries and the Salivary Proline-Rich Proteins. International Journal of Dentistry No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-511050
American Medical Association (AMA)
Levine, Martin. Susceptibility to Dental Caries and the Salivary Proline-Rich Proteins. International Journal of Dentistry. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-511050
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511050