Should Aggressive Surgical Local Control Be Attempted in All Patients with Metastatic or Pelvic Ewing's Sarcoma?
Joint Authors
Weiss, Kurt R.
Thorpe, Steven W.
Goodman, Mark A.
McGough, Richard L.
Heyl, Alma E.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
In previous reports, patients with Ewing's sarcoma received radiation therapy (XRT) for definitive local control because metastatic disease and pelvic location were thought to preclude aggressive local treatment.
We sought to determine if single-site metastatic disease should be treated differently from multicentric-metastatic disease.
We also wanted to reinvestigate the impact of XRT, pelvic location, and local recurrence on outcomes.
Our results demonstrated a significant difference in overall survival (OS) between patients with either localized disease or a single-metastatic site and patients with multicentric-metastatic disease (P=0.004).
Local control was also found to be an independent predictor of outcomes as demonstrated by a significant difference in OS between those with and without local recurrence (P=0.001).
Axial and pelvic location did not predict a decreased OS.
Based on these results, we concluded that pelvic location and the diagnosis of metastatic disease at diagnosis should not preclude aggressive local control, except in cases of multicentric-metastatic disease.
American Psychological Association (APA)
Thorpe, Steven W.& Weiss, Kurt R.& Goodman, Mark A.& Heyl, Alma E.& McGough, Richard L.. 2012. Should Aggressive Surgical Local Control Be Attempted in All Patients with Metastatic or Pelvic Ewing's Sarcoma?. Sarcoma،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-511068
Modern Language Association (MLA)
Thorpe, Steven W.…[et al.]. Should Aggressive Surgical Local Control Be Attempted in All Patients with Metastatic or Pelvic Ewing's Sarcoma?. Sarcoma No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-511068
American Medical Association (AMA)
Thorpe, Steven W.& Weiss, Kurt R.& Goodman, Mark A.& Heyl, Alma E.& McGough, Richard L.. Should Aggressive Surgical Local Control Be Attempted in All Patients with Metastatic or Pelvic Ewing's Sarcoma?. Sarcoma. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-511068
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511068