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Interactive Effects of Morphine on HIV Infection : Role in HIV-Associated Neurocognitive Disorder
Joint Authors
Reddy, Pichili Vijaya Bhaskar
Saiyed, Zainulabedin
Saxena, Shailendra K.
Nair, Madhavan P. N.
Pilakka-Kanthikeel, Sudheesh
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
HIV epidemic continues to be a severe public health problem and concern within USA and across the globe with about 33 million people infected with HIV.
The frequency of drug abuse among HIV infected patients is rapidly increasing and is another major issue since injection drug users are at a greater risk of developing HIV associated neurocognitive dysfunctions compared to non-drug users infected with HIV.
Brain is a major target for many of the recreational drugs and HIV.
Evidences suggest that opiate drug abuse is a risk factor in HIV infection, neural dysfunction and progression to AIDS.
The information available on the role of morphine as a cofactor in the neuropathogenesis of HIV is scanty.
This review summarizes the results that help in understanding the role of morphine use in HIV infection and neural dysfunction.
Studies show that morphine enhances HIV-1 infection by suppressing IL-8, downregulating chemokines with reciprocal upregulation of HIV coreceptors.
Morphine also activates MAPK signaling and downregulates cAMP response element-binding protein (CREB).
Better understanding on the role of morphine in HIV infection and mechanisms through which morphine mediates its effects may help in devising novel therapeutic strategies against HIV-1 infection in opiate using HIV-infected population.
American Psychological Association (APA)
Reddy, Pichili Vijaya Bhaskar& Pilakka-Kanthikeel, Sudheesh& Saxena, Shailendra K.& Saiyed, Zainulabedin& Nair, Madhavan P. N.. 2012. Interactive Effects of Morphine on HIV Infection : Role in HIV-Associated Neurocognitive Disorder. AIDS Research and Treatment،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-511075
Modern Language Association (MLA)
Reddy, Pichili Vijaya Bhaskar…[et al.]. Interactive Effects of Morphine on HIV Infection : Role in HIV-Associated Neurocognitive Disorder. AIDS Research and Treatment No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-511075
American Medical Association (AMA)
Reddy, Pichili Vijaya Bhaskar& Pilakka-Kanthikeel, Sudheesh& Saxena, Shailendra K.& Saiyed, Zainulabedin& Nair, Madhavan P. N.. Interactive Effects of Morphine on HIV Infection : Role in HIV-Associated Neurocognitive Disorder. AIDS Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-511075
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511075