Feasibility of Imaging Myelin Lesions in Multiple Sclerosis
Joint Authors
Graf, John F.
Tan Hehir, Cristina A.
Zavodszky, Maria I.
Source
International Journal of Biomedical Imaging
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-15
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The goal of this study was to provide a feasibility assessment for PET imaging of multiple sclerosis (MS) lesions based on their decreased myelin content relative to the surrounding normal-appearing brain tissue.
The imaging agent evaluated for this purpose is a molecule that binds strongly and specifically to myelin basic protein.
Physiology-based pharmacokinetic modeling combined with PET image simulation applied to a brain model was used to examine whether such an agent would allow the differentiation of artificial lesions 4–10 mm in diameter from the surrounding normal-looking white and gray matter.
Furthermore, we examined how changes in agent properties, model parameters, and experimental conditions can influence imageability, identifying a set of conditions under which imaging of MS lesions might be feasible.
Based on our results, we concluded that PET imaging has the potential to become a useful complementary method to MRI for MS diagnosis and therapy monitoring.
American Psychological Association (APA)
Zavodszky, Maria I.& Graf, John F.& Tan Hehir, Cristina A.. 2011. Feasibility of Imaging Myelin Lesions in Multiple Sclerosis. International Journal of Biomedical Imaging،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-511089
Modern Language Association (MLA)
Zavodszky, Maria I.…[et al.]. Feasibility of Imaging Myelin Lesions in Multiple Sclerosis. International Journal of Biomedical Imaging No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-511089
American Medical Association (AMA)
Zavodszky, Maria I.& Graf, John F.& Tan Hehir, Cristina A.. Feasibility of Imaging Myelin Lesions in Multiple Sclerosis. International Journal of Biomedical Imaging. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-511089
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511089