An Overview of the Statistical Methods Used for Inferring Gene Regulatory Networks and Protein-Protein Interaction Networks
Joint Authors
Nounou, Hazem N.
Chouchane, Lotfi
Noor, Amina
Serpedin, Erchin
Mohamed, Nady
Nounou, Mohamed N.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-21
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
The large influx of data from high-throughput genomic and proteomic technologies has encouraged the researchers to seek approaches for understanding the structure of gene regulatory networks and proteomic networks.
This work reviews some of the most important statistical methods used for modeling of gene regulatory networks (GRNs) and protein-protein interaction (PPI) networks.
The paper focuses on the recent advances in the statistical graphical modeling techniques, state-space representation models, and information theoretic methods that were proposed for inferring the topology of GRNs.
It appears that the problem of inferring the structure of PPI networks is quite different from that of GRNs.
Clustering and probabilistic graphical modeling techniques are of prime importance in the statistical inference of PPI networks, and some of the recent approaches using these techniques are also reviewed in this paper.
Performance evaluation criteria for the approaches used for modeling GRNs and PPI networks are also discussed.
American Psychological Association (APA)
Noor, Amina& Serpedin, Erchin& Nounou, Mohamed N.& Nounou, Hazem N.& Mohamed, Nady& Chouchane, Lotfi. 2013. An Overview of the Statistical Methods Used for Inferring Gene Regulatory Networks and Protein-Protein Interaction Networks. Advances in Bioinformatics،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-511090
Modern Language Association (MLA)
Noor, Amina…[et al.]. An Overview of the Statistical Methods Used for Inferring Gene Regulatory Networks and Protein-Protein Interaction Networks. Advances in Bioinformatics No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-511090
American Medical Association (AMA)
Noor, Amina& Serpedin, Erchin& Nounou, Mohamed N.& Nounou, Hazem N.& Mohamed, Nady& Chouchane, Lotfi. An Overview of the Statistical Methods Used for Inferring Gene Regulatory Networks and Protein-Protein Interaction Networks. Advances in Bioinformatics. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-511090
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511090