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Thrombotic Thrombocytopenic Purpura Associated with Mixed Connective Tissue Disease : A Case Report
Joint Authors
da Silva, Aline Maria Yamaguti Rios Paes
Barbosa, Fernanda Alves
Ribas, Gustavo Fernandes
de Barros, Philipe Vianna
Souto Filho, João Tadeu Damian
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-11
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Thrombotic thrombocytopenic purpura (TTP) is a multisystemic disorder characterized by microangiopathic hemolytic anemia and thrombocytopenia, which may be accompanied by fever, renal, or neurologic abnormalities.
Cases are divided into acute idiopathic TTP and secondary TTP.
Autoimmune diseases, especially systemic lupus erythematosus, in association with TTP have been described so far in many patients.
In contrast, TTP occurring in a patient with mixed connected tissue disease (MCTD) is extremely rare and has only been described in nine patients.
We describe the case of a 42-year-old female with MCTD who developed thrombocytopenia, microangiopathic hemolytic anemia, fever, and neurological symptoms.
The patient had a good clinical evolution with infusion of high volume of fresh frozen plasma, steroid therapy, and support in an intensive care unit.
Although the occurrence of TTP is rare in MCTD patients, it is important to recognize TTP as a cause of thrombocytopenia and hemolytic anemia in any patient with autoimmune diseases.
Prompt institution of treatment remains the cornerstone of treatment of TTP even if plasma exchange is not available like what frequently happens in developing countries.
American Psychological Association (APA)
Souto Filho, João Tadeu Damian& de Barros, Philipe Vianna& da Silva, Aline Maria Yamaguti Rios Paes& Barbosa, Fernanda Alves& Ribas, Gustavo Fernandes. 2011. Thrombotic Thrombocytopenic Purpura Associated with Mixed Connective Tissue Disease : A Case Report. Case Reports in Medicine،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-511099
Modern Language Association (MLA)
Souto Filho, João Tadeu Damian…[et al.]. Thrombotic Thrombocytopenic Purpura Associated with Mixed Connective Tissue Disease : A Case Report. Case Reports in Medicine No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-511099
American Medical Association (AMA)
Souto Filho, João Tadeu Damian& de Barros, Philipe Vianna& da Silva, Aline Maria Yamaguti Rios Paes& Barbosa, Fernanda Alves& Ribas, Gustavo Fernandes. Thrombotic Thrombocytopenic Purpura Associated with Mixed Connective Tissue Disease : A Case Report. Case Reports in Medicine. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-511099
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511099