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The Bone Marrow Microenvironment as Niche Retreats for Hematopoietic and Leukemic Stem Cells
Joint Authors
Konopleva, Marina
Nwajei, Felix
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Leukemia poses a serious challenge to current therapeutic strategies.
This has been attributed to leukemia stem cells (LSCs), which occupy endosteal and sinusoidal niches in the bone marrow similar to those of hematopoietic stem cells (HSCs).
The signals from these niches provide a viable setting for the maintenance, survival, and fate specifications of these stem cells.
Advancements in genetic engineering and microscopy have enabled us to critically deconstruct and analyze the anatomic and functional characteristics of these niches to reveal a wealth of new knowledge in HSC biology, which is quite ahead of LSC biology.
In this paper, we examine the present understanding of the regulatory mechanisms governing HSC niches, with the goals of providing a framework for understanding the mechanisms of LSC regulation and suggesting future strategies for their elimination.
American Psychological Association (APA)
Nwajei, Felix& Konopleva, Marina. 2013. The Bone Marrow Microenvironment as Niche Retreats for Hematopoietic and Leukemic Stem Cells. Advances in Hematology،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-511108
Modern Language Association (MLA)
Nwajei, Felix& Konopleva, Marina. The Bone Marrow Microenvironment as Niche Retreats for Hematopoietic and Leukemic Stem Cells. Advances in Hematology No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-511108
American Medical Association (AMA)
Nwajei, Felix& Konopleva, Marina. The Bone Marrow Microenvironment as Niche Retreats for Hematopoietic and Leukemic Stem Cells. Advances in Hematology. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-511108
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511108