The Prognostic Significance of Lymphatics in Colorectal Liver Metastases
Joint Authors
Muralidharan, Vijayaragavan
Christophi, Christopher
Nguyen, Linh
Banting, Jonathan
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Colorectal Cancer (CRC) is the most common form of cancer diagnosed in Australia across both genders.
Approximately, 40%–60% of patients with CRC develop metastasis, the liver being the most common site.
Almost 70% of CRC mortality can be attributed to the development of liver metastasis.
This study examines the pattern and density of lymphatics in colorectal liver metastases (CLM) as predictors of survival following hepatic resection for CLM.
Methods.
Patient tissue samples were obtained from the Victorian Cancer Biobank.
Immunohistochemistry was used to examine the spatial differences in blood and lymphatic vessel densities between different regions within the tumor (CLM) and surrounding host tissue.
Lymphatic vessel density (LVD) was assessed as a potential prognostic marker.
Results.
Patients with low lymphatic vessel density in the tumor centre, tumor periphery, and adjacent normal liver demonstrated a significant disease-free survival advantage compared to patients with high lymphatic vessel density (P=0.01, P>0.01, and P=0.05, resp.).
Lymphatic vessel density in the tumor centre and periphery and adjacent normal liver was an accurate predictive marker of disease-free survival (P=0.05).
Conclusion.
Lymphatic vessel density in CLM appears to be an accurate predictor of recurrence and disease-free survival.
American Psychological Association (APA)
Muralidharan, Vijayaragavan& Nguyen, Linh& Banting, Jonathan& Christophi, Christopher. 2014. The Prognostic Significance of Lymphatics in Colorectal Liver Metastases. HPB Surgery،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-511168
Modern Language Association (MLA)
Muralidharan, Vijayaragavan…[et al.]. The Prognostic Significance of Lymphatics in Colorectal Liver Metastases. HPB Surgery No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-511168
American Medical Association (AMA)
Muralidharan, Vijayaragavan& Nguyen, Linh& Banting, Jonathan& Christophi, Christopher. The Prognostic Significance of Lymphatics in Colorectal Liver Metastases. HPB Surgery. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-511168
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511168