Molecular Mechanisms for Biliary Phospholipid and Drug Efflux Mediated by ABCB4 and Bile Salts
Joint Authors
Terada, Tomohiro
Morita, Shin-ya
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-15
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
On the canalicular membranes of hepatocytes, several ABC transporters are responsible for the secretion of bile lipids.
Among them, ABCB4, also called MDR3, is essential for the secretion of phospholipids from hepatocytes into bile.
The biliary phospholipids are associated with bile salts and cholesterol in mixed micelles, thereby reducing the detergent activity and cytotoxicity of bile salts and preventing cholesterol crystallization.
Mutations in the ABCB4 gene result in progressive familial intrahepatic cholestasis type 3, intrahepatic cholestasis of pregnancy, low-phospholipid-associated cholelithiasis, primary biliary cirrhosis, and cholangiocarcinoma.
In vivo and cell culture studies have demonstrated that the secretion of biliary phospholipids depends on both ABCB4 expression and bile salts.
In the presence of bile salts, ABCB4 located in nonraft membranes mediates the efflux of phospholipids, preferentially phosphatidylcholine.
Despite high homology with ABCB1, ABCB4 expression cannot confer multidrug resistance.
This review summarizes our current understanding of ABCB4 functions and physiological relevance, and discusses the molecular mechanism for the ABCB4-mediated efflux of phospholipids.
American Psychological Association (APA)
Morita, Shin-ya& Terada, Tomohiro. 2014. Molecular Mechanisms for Biliary Phospholipid and Drug Efflux Mediated by ABCB4 and Bile Salts. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-511183
Modern Language Association (MLA)
Morita, Shin-ya& Terada, Tomohiro. Molecular Mechanisms for Biliary Phospholipid and Drug Efflux Mediated by ABCB4 and Bile Salts. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-511183
American Medical Association (AMA)
Morita, Shin-ya& Terada, Tomohiro. Molecular Mechanisms for Biliary Phospholipid and Drug Efflux Mediated by ABCB4 and Bile Salts. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-511183
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511183