Endotoxin Binding by Sevelamer : Potential Impact on Nutritional Status

Joint Authors

Kubotera, Natsuki
Prokopienko, Alexander J.
Garba, Adinoyi O.
Pai, Amy Barton

Source

International Journal of Nephrology

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-01-17

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Diseases
Medicine

Abstract EN

Patients on hemodialysis (HD) have a high burden of chronic inflammation induced associated with multiple comorbidities including poor nutritional status.

Endotoxin (ET) is a Gram-negative bacterial cell wall component and a potent stimulus for innate immune system activation leading to the transcription of proinflammatory cytokines (e.g., IL-1, IL-6, and TNFα) that adversely affect protein metabolism and nutrition.

Several cross-sectional observational studies have found that elevated serum ET concentrations in hemodialysis patients are associated with lower serum albumin, higher proinflammatory cytokine, and C-reactive protein concentrations.

Possible sources of ET in the systemic circulation are bacterial translocation from the gastrointestinal tract and iron supplementation, potentially leading to intestinal bacterial overgrowth.

Sevelamer is a nonabsorbable hydrogel approved for use as a phosphate binder in HD patients.

Reductions in serum ET concentrations in hemodialysis patients have been observed with sevelamer therapy in observational studies and the few published interventional studies.

Reduction of ET concentrations was associated with concomitant reductions in TNFα, IL-6, and CRP and improvement in serum albumin in the majority of these small studies.

Additional studies are needed to evaluate the potential effects of sevelamer treatment on nutritional status in chronic kidney disease (CKD) patients with elevated ET.

American Psychological Association (APA)

Kubotera, Natsuki& Prokopienko, Alexander J.& Garba, Adinoyi O.& Pai, Amy Barton. 2013. Endotoxin Binding by Sevelamer : Potential Impact on Nutritional Status. International Journal of Nephrology،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-511196

Modern Language Association (MLA)

Kubotera, Natsuki…[et al.]. Endotoxin Binding by Sevelamer : Potential Impact on Nutritional Status. International Journal of Nephrology No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-511196

American Medical Association (AMA)

Kubotera, Natsuki& Prokopienko, Alexander J.& Garba, Adinoyi O.& Pai, Amy Barton. Endotoxin Binding by Sevelamer : Potential Impact on Nutritional Status. International Journal of Nephrology. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-511196

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-511196