Thickness in Entorhinal and Subicular Cortex Predicts Episodic Memory Decline in Mild Cognitive Impairment
Joint Authors
Miller, Karen J.
Bookheimer, Susan Y.
Suthana, N. A.
Small, Gary W.
Jones, M.
Burggren, A. C.
Renner, B.
Ercoli, L. M.
Donix, M.
Martin-Harris, L.
Siddarth, P.
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Identifying subjects with mild cognitive impairment (MCI) most likely to decline in cognition over time is a major focus in Alzheimer's disease (AD) research.
Neuroimaging biomarkers that predict decline would have great potential for increasing the efficacy of early intervention.
In this study, we used high-resolution MRI, combined with a cortical unfolding technique to increase visibility of the convoluted medial temporal lobe (MTL), to assess whether gray matter thickness in subjects with MCI correlated to decline in cognition over two years.
We found that thickness in the entorhinal (ERC) and subicular (Sub) cortices of MCI subjects at initial assessment correlated to change in memory encoding over two years (ERC: r=0.34; P=.003) and Sub (r=0.26; P=.011) but not delayed recall performance.
Our findings suggest that aspects of memory performance may be differentially affected in the early stages of AD.
Given the MTL's involvement in early stages of neurodegeneration in AD, clarifying the relationship of these brain regions and the link to resultant cognitive decline is critical in understanding disease progression.
American Psychological Association (APA)
Burggren, A. C.& Renner, B.& Jones, M.& Donix, M.& Suthana, N. A.& Martin-Harris, L.…[et al.]. 2011. Thickness in Entorhinal and Subicular Cortex Predicts Episodic Memory Decline in Mild Cognitive Impairment. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-511204
Modern Language Association (MLA)
Burggren, A. C.…[et al.]. Thickness in Entorhinal and Subicular Cortex Predicts Episodic Memory Decline in Mild Cognitive Impairment. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-511204
American Medical Association (AMA)
Burggren, A. C.& Renner, B.& Jones, M.& Donix, M.& Suthana, N. A.& Martin-Harris, L.…[et al.]. Thickness in Entorhinal and Subicular Cortex Predicts Episodic Memory Decline in Mild Cognitive Impairment. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-511204
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511204