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Ovarian Reserve in Women Treated for Acute Lymphocytic Leukemia or Acute Myeloid Leukemia with Chemotherapy, but Not Stem Cell Transplantation
Joint Authors
Wadleigh, Martha
Correia, Katharine F.
Missmer, Stacey
Ginsburg, Elizabeth S.
Rossi, Brooke V.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-20
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Purpose.
It is well known that chemotherapy regimens may have a negative effect on ovarian reserve, leading to amenorrhea or premature ovarian failure.
There are little data regarding the effects of leukemia chemotherapy on ovarian reserve, specifically in women who received the chemotherapy as adults and are having regular menstrual periods.
Our primary objective was to determine if premenopausal women with a history of chemotherapy for leukemia, without subsequent stem cell transplantation, have decreased ovarian reserve.
Materials and Methods.
We measured ovarian reserve in five women who had been treated for acute lymphocytic leukemia (ALL) or acute myeloid leukemia (AML) and compared them to age-matched control women without a history of chemotherapy.
Results.
There appeared to be a trend towards lower antimullerian hormone and antral follicle counts and higher follicle-stimulating hormone levels in the leukemia group.
Conclusion.
Our results indicate that chemotherapy for AML or ALL without stem cell transplantation may compromise ovarian reserve.
Although our results should be confirmed by a larger study, oncologists, infertility specialists, and patients should be aware of the potential risks to ovarian function and should be counseled on options for fertility preservation.
American Psychological Association (APA)
Rossi, Brooke V.& Missmer, Stacey& Correia, Katharine F.& Wadleigh, Martha& Ginsburg, Elizabeth S.. 2012. Ovarian Reserve in Women Treated for Acute Lymphocytic Leukemia or Acute Myeloid Leukemia with Chemotherapy, but Not Stem Cell Transplantation. ISRN Oncology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-511221
Modern Language Association (MLA)
Rossi, Brooke V.…[et al.]. Ovarian Reserve in Women Treated for Acute Lymphocytic Leukemia or Acute Myeloid Leukemia with Chemotherapy, but Not Stem Cell Transplantation. ISRN Oncology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-511221
American Medical Association (AMA)
Rossi, Brooke V.& Missmer, Stacey& Correia, Katharine F.& Wadleigh, Martha& Ginsburg, Elizabeth S.. Ovarian Reserve in Women Treated for Acute Lymphocytic Leukemia or Acute Myeloid Leukemia with Chemotherapy, but Not Stem Cell Transplantation. ISRN Oncology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-511221
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511221