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Tracking Regional Tissue Volume and Function Change in Lung Using Image Registration
Joint Authors
Hoffman, Eric A.
Baker, Kimberly M.
Raghavan, Maghavan L.
Du, Kaifang
Amelon, Ryan E.
Cao, Kunlin
Reinhardt, Joseph M.
Ding, Kai
Christensen, Gary E.
Source
International Journal of Biomedical Imaging
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-18
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
We have previously demonstrated the 24-hour redistribution and reabsorption of bronchoalveolar lavage (BAL) fluid delivered to the lung during a bronchoscopic procedure in normal volunteers.
In this work we utilize image-matching procedures to correlate fluid redistribution and reabsorption to changes in regional lung function.
Lung CT datasets from six human subjects were used in this study.
Each subject was scanned at four time points before and after BAL procedure.
Image registration was performed to align images at different time points and different inflation levels.
The resulting dense displacement fields were utilized to track tissue volume changes and reveal deformation patterns of local parenchymal tissue quantitatively.
The registration accuracy was assessed by measuring landmark matching errors, which were on the order of 1 mm.
The results show that quantitative-assessed fluid volume agreed well with bronchoscopist-reported unretrieved BAL volume in the whole lungs (squared linear correlation coefficient was 0.81).
The average difference of lung tissue volume at baseline and after 24 hours was around 2%, which indicates that BAL fluid in the lungs was almost absorbed after 24 hours.
Regional lung-function changes correlated with the presence of BAL fluid, and regional function returned to baseline as the fluid was reabsorbed.
American Psychological Association (APA)
Cao, Kunlin& Christensen, Gary E.& Ding, Kai& Du, Kaifang& Raghavan, Maghavan L.& Amelon, Ryan E.…[et al.]. 2012. Tracking Regional Tissue Volume and Function Change in Lung Using Image Registration. International Journal of Biomedical Imaging،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-511226
Modern Language Association (MLA)
Cao, Kunlin…[et al.]. Tracking Regional Tissue Volume and Function Change in Lung Using Image Registration. International Journal of Biomedical Imaging No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-511226
American Medical Association (AMA)
Cao, Kunlin& Christensen, Gary E.& Ding, Kai& Du, Kaifang& Raghavan, Maghavan L.& Amelon, Ryan E.…[et al.]. Tracking Regional Tissue Volume and Function Change in Lung Using Image Registration. International Journal of Biomedical Imaging. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-511226
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511226