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Controversies of Treatment Modalities for Cerebral Venous Thrombosis
Joint Authors
Wasay, Mohammad
Kamal, Ayeesha Kamran
Khan, Maria
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Cerebral vein thrombosis has been well recognized for nearly two centuries.
However, therapeutic options for the condition are limited due to lack of large randomized trials.
The various modalities reportedly used include antiplatelets, anticoagulation, fibrinolysis, and mechanical thrombectomy.
Of these, antiplatelets are the least studied, and there are only anecdotal reports of aspirin use.
Anticoagulation is the most widely used and accepted modality with favorable outcomes documented in two randomized controlled trials.
Various fibrinolytic agents have also been tried.
Local infusions have shown more promise compared to systemic agents.
Similarly, mechanical thrombectomy has been used to augment the effects of chemical thrombolysis.
However, in the absence of randomized controlled trials; there is no concrete evidence of the safety and efficacy of either of these modalities.
Limited study series disclosed that decompression surgery in malignant CVT can be life saving and provides good neurological outcome in some cases.
Conclusion.
Overall therapeutics for CVT need larger randomized controlled trials.
Anticoagulaion with heparin is the only modality with a reasonable evidence to support its use in CVT.
Endovascular thrombolysis and mechanical thrombectomy are reserved for selected cases who fail anticoagulation and decompression surgery for malignant CVT with impending herniation.
American Psychological Association (APA)
Khan, Maria& Kamal, Ayeesha Kamran& Wasay, Mohammad. 2010. Controversies of Treatment Modalities for Cerebral Venous Thrombosis. Stroke Research and Treatment،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-511229
Modern Language Association (MLA)
Khan, Maria…[et al.]. Controversies of Treatment Modalities for Cerebral Venous Thrombosis. Stroke Research and Treatment No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-511229
American Medical Association (AMA)
Khan, Maria& Kamal, Ayeesha Kamran& Wasay, Mohammad. Controversies of Treatment Modalities for Cerebral Venous Thrombosis. Stroke Research and Treatment. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-511229
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511229