Chimeric Antigen Receptor-Engineered T Cells for Immunotherapy of Cancer
Joint Authors
Stamova, Slava
Feldmann, Anja
Cartellieri, Marc
Wehner, Rebekka
Bachmann, Michael
Schmitz, Marc
Bippes, Claudia
Temme, Achim
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-05
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
CD4+ and CD8+ T lymphocytes are powerful components of adaptive immunity, which essentially contribute to the elimination of tumors.
Due to their cytotoxic capacity, T cells emerged as attractive candidates for specific immunotherapy of cancer.
A promising approach is the genetic modification of T cells with chimeric antigen receptors (CARs).
First generation CARs consist of a binding moiety specifically recognizing a tumor cell surface antigen and a lymphocyte activating signaling chain.
The CAR-mediated recognition induces cytokine production and tumor-directed cytotoxicity of T cells.
Second and third generation CARs include signal sequences from various costimulatory molecules resulting in enhanced T-cell persistence and sustained antitumor reaction.
Clinical trials revealed that the adoptive transfer of T cells engineered with first generation CARs represents a feasible concept for the induction of clinical responses in some tumor patients.
However, further improvement is required, which may be achieved by second or third generation CAR-engrafted T cells.
American Psychological Association (APA)
Cartellieri, Marc& Bachmann, Michael& Feldmann, Anja& Bippes, Claudia& Stamova, Slava& Wehner, Rebekka…[et al.]. 2010. Chimeric Antigen Receptor-Engineered T Cells for Immunotherapy of Cancer. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-511230
Modern Language Association (MLA)
Cartellieri, Marc…[et al.]. Chimeric Antigen Receptor-Engineered T Cells for Immunotherapy of Cancer. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-13.
https://search.emarefa.net/detail/BIM-511230
American Medical Association (AMA)
Cartellieri, Marc& Bachmann, Michael& Feldmann, Anja& Bippes, Claudia& Stamova, Slava& Wehner, Rebekka…[et al.]. Chimeric Antigen Receptor-Engineered T Cells for Immunotherapy of Cancer. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-511230
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511230