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An Unusual Case of Anti-GBM Antibody Elevation in HIV-Associated Nephropathy
Joint Authors
Minocha, Vinay
Makary, Raafat
Poenariu, Andreea
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Introduction.
The most commonly seen glomerular disease in HIV infected patients is HIV-associated nephropathy (HIVAN); however, a multitude of other nephropathies can occur in HIV infection with an almost equal cumulative frequency.
We report an unusual case of a patient with clinical and histological evidence of HIVAN in which the diagnosis was initially confounded by the finding of an elevated serum anti-glomerular basement membrane (anti-GBM) antibody.
Case Presentation.
We present a case of a 27-year-old African American female with a history of schizophrenia, cocaine abuse, and HIV infection who upon admission to our hospital was found to have severe acute kidney injury requiring hemodialysis.
Urine studies revealed nephrotic range proteinuria and a serological workup was positive for anti-GBM antibody elevation with a value of 91 units (normal: 0–20 units).
A renal biopsy revealed HIVAN with no evidence of crescentic glomerulonephritis or anti-GBM disease.
Conclusion.
This case highlights the need for careful interpretation of anti-GBM antibody tests in HIV infected patients with kidney disease and, in particular, the need for biopsy confirmation of the diagnosis prior to starting therapy.
More research is needed to study the prognostic correlation between the degree of anti-GBM antibody elevation in HIVAN and disease severity.
American Psychological Association (APA)
Minocha, Vinay& Makary, Raafat& Poenariu, Andreea. 2014. An Unusual Case of Anti-GBM Antibody Elevation in HIV-Associated Nephropathy. Case Reports in Nephrology،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-511252
Modern Language Association (MLA)
Minocha, Vinay…[et al.]. An Unusual Case of Anti-GBM Antibody Elevation in HIV-Associated Nephropathy. Case Reports in Nephrology No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-511252
American Medical Association (AMA)
Minocha, Vinay& Makary, Raafat& Poenariu, Andreea. An Unusual Case of Anti-GBM Antibody Elevation in HIV-Associated Nephropathy. Case Reports in Nephrology. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-511252
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511252