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Achieving the Balance between ROS and Antioxidants : When to Use the Synthetic Antioxidants
Joint Authors
Milisav, Irina
Poljsak, Borut
Šuput, Dušan
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-29
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Free radical damage is linked to formation of many degenerative diseases, including cancer, cardiovascular disease, cataracts, and aging.
Excessive reactive oxygen species (ROS) formation can induce oxidative stress, leading to cell damage that can culminate in cell death.
Therefore, cells have antioxidant networks to scavenge excessively produced ROS.
The balance between the production and scavenging of ROS leads to homeostasis in general; however, the balance is somehow shifted towards the formation of free radicals, which results in accumulated cell damage in time.
Antioxidants can attenuate the damaging effects of ROS in vitro and delay many events that contribute to cellular aging.
The use of multivitamin/mineral supplements (MVMs) has grown rapidly over the past decades.
Some recent studies demonstrated no effect of antioxidant therapy; sometimes the intake of antioxidants even increased mortality.
Oxidative stress is damaging and beneficial for the organism, as some ROS are signaling molecules in cellular signaling pathways.
Lowering the levels of oxidative stress by antioxidant supplements is not beneficial in such cases.
The balance between ROS and antioxidants is optimal, as both extremes, oxidative and antioxidative stress, are damaging.
Therefore, there is a need for accurate determination of individual's oxidative stress levels before prescribing the supplement antioxidants.
American Psychological Association (APA)
Poljsak, Borut& Šuput, Dušan& Milisav, Irina. 2013. Achieving the Balance between ROS and Antioxidants : When to Use the Synthetic Antioxidants. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-511270
Modern Language Association (MLA)
Poljsak, Borut…[et al.]. Achieving the Balance between ROS and Antioxidants : When to Use the Synthetic Antioxidants. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-511270
American Medical Association (AMA)
Poljsak, Borut& Šuput, Dušan& Milisav, Irina. Achieving the Balance between ROS and Antioxidants : When to Use the Synthetic Antioxidants. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-511270
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511270