Application of Bioluminescence Imaging for In Vivo Monitoring of Fungal Infections
Author
Source
International Journal of Microbiology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Abstract EN
Fungi can cause severe invasive infections especially in the immunocompromised host.
Patient populations at risk are increasing due to ongoing developments in cancer treatment and transplantation medicine.
Only limited diagnostic tools and few antifungals are available, rendering a significant number of invasive fungal infections life threatening.
To reduce mortality rates, a better understanding of the infection processes is urgently required.
Bioluminescence imaging (BLI) is a powerful tool for such purposes, since it allows visualisation of temporal and spatial progression of infections in real time.
BLI has been successfully used to monitor infections caused by various microorganisms, in particular bacteria.
However, first studies have also been performed on the fungi Candida albicans and Aspergillus fumigatus.
Although BLI was, in principle, suitable to study the infection process, some limitations remained.
Here, different luciferase systems are introduced, and current approaches are summarised.
Finally, suggestions for further improvements of BLI to monitor fungal infections are provided.
American Psychological Association (APA)
Brock, Matthias. 2011. Application of Bioluminescence Imaging for In Vivo Monitoring of Fungal Infections. International Journal of Microbiology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-511271
Modern Language Association (MLA)
Brock, Matthias. Application of Bioluminescence Imaging for In Vivo Monitoring of Fungal Infections. International Journal of Microbiology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-511271
American Medical Association (AMA)
Brock, Matthias. Application of Bioluminescence Imaging for In Vivo Monitoring of Fungal Infections. International Journal of Microbiology. 2011. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-511271
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511271