DNA Methylation, Histone Modifications, and Signal Transduction Pathways : A Close Relationship in Malignant Gliomas Pathophysiology
Joint Authors
Alelú-Paz, Raúl
González-Corpas, Ana
Ropero, Santiago
Ashour, Nadia
Source
Journal of Signal Transduction
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Gliomas are the most common type of primary brain tumor.
Although tremendous progress has been achieved in the recent years in the diagnosis and treatment, its molecular etiology remains unknown.
In this regard, epigenetics represents a new approach to study the mechanisms that control gene expression and function without changing the sequence of the genome.
In the present paper we describe the main findings about the alterations of cell signaling pathways in the most aggressive glioma in the adult population, namely, glioblastoma, in which epigenetic mechanisms and the emerging role of cancer stem cell play a crucial function in the development of new biomarkers for its detection and prognosis and the corresponding development of new pharmacological strategies.
American Psychological Association (APA)
Alelú-Paz, Raúl& Ashour, Nadia& González-Corpas, Ana& Ropero, Santiago. 2012. DNA Methylation, Histone Modifications, and Signal Transduction Pathways : A Close Relationship in Malignant Gliomas Pathophysiology. Journal of Signal Transduction،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-511293
Modern Language Association (MLA)
Alelú-Paz, Raúl…[et al.]. DNA Methylation, Histone Modifications, and Signal Transduction Pathways : A Close Relationship in Malignant Gliomas Pathophysiology. Journal of Signal Transduction No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-511293
American Medical Association (AMA)
Alelú-Paz, Raúl& Ashour, Nadia& González-Corpas, Ana& Ropero, Santiago. DNA Methylation, Histone Modifications, and Signal Transduction Pathways : A Close Relationship in Malignant Gliomas Pathophysiology. Journal of Signal Transduction. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-511293
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511293