Proximal Tubule Cell Hypothesis for Cardiorenal Syndrome in Diabetes
Joint Authors
Hosojima, Michihiro
Saito, Akihiko
Kaseda, Ryohei
Sato, Hiroyoshi
Source
International Journal of Nephrology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-09
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Incidence of cardiovascular disease (CVD) is remarkably high among patients with chronic kidney disease (CKD), even in the early microalbuminuric stages with normal glomerular filtration rates.
Proximal tubule cells (PTCs) mediate metabolism and urinary excretion of vasculotoxic substances via apical and basolateral receptors and transporters.
These cells also retrieve vasculoprotective substances from circulation or synthesize them for release into the circulation.
PTCs are also involved in the uptake of sodium and phosphate, which are critical for hemodynamic regulation and maintaining the mineral balance, respectively.
Dysregulation of PTC functions in CKD is likely to be associated with the development of CVD and is linked to the progression to end-stage renal disease.
In particular, PTC dysfunction occurs early in diabetic nephropathy, a leading cause of CKD.
It is therefore important to elucidate the mechanisms of PTC dysfunction to develop therapeutic strategies for treating cardiorenal syndrome in diabetes.
American Psychological Association (APA)
Saito, Akihiko& Kaseda, Ryohei& Hosojima, Michihiro& Sato, Hiroyoshi. 2010. Proximal Tubule Cell Hypothesis for Cardiorenal Syndrome in Diabetes. International Journal of Nephrology،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-511316
Modern Language Association (MLA)
Saito, Akihiko…[et al.]. Proximal Tubule Cell Hypothesis for Cardiorenal Syndrome in Diabetes. International Journal of Nephrology No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-511316
American Medical Association (AMA)
Saito, Akihiko& Kaseda, Ryohei& Hosojima, Michihiro& Sato, Hiroyoshi. Proximal Tubule Cell Hypothesis for Cardiorenal Syndrome in Diabetes. International Journal of Nephrology. 2010. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-511316
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511316