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Altered p16INK4 and RB1 Expressions Are Associated with Poor Prognosis in Patients with Nonsmall Cell Lung Cancer
Joint Authors
Otterson, Gregory A.
Tang, Yan
Leon, Marino E.
Zhao, Weiqiang
Villalona, Miguel A.
Huang, Cheng C.
Shilo, Konstantin
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
p16INK4 and RB1 are two potent cell cycle regulators to control the G1/S transition by interacting with CDK4/6, E2F, and D-type cyclins, respectively.
Depending on the tumour type, genetic alterations resulting in the functional inactivation have frequently been reported in both genes.
By contrast, much less is known regarding the overexpression of these proteins in the tumor cells.
In this study, expressions of p16INK4 RB1, and CDKN2A copy number variances (CNV) in the tumor cells were assessed by immunohistochemistry and fluorescence in situ hybridization (FISH), respectively, in 73 nonsmall cell lung cancer (NSCLC) with known 5-year survivals.
The histologic type (P=0.01), p16INK4 (P=0.004), and RB1 (P<0.001) were predictive of survivals.
The CDKN2A CNV (P<0.05) was also significant when compared to those cases without CNV.
Therefore, among the molecular genetic prognostic factors, expressions of RB1 and p16INK4 in the tumor cells were the most strongly predictive of adverse outcomes in stage I and II nonsquamous NSCLC.
American Psychological Association (APA)
Zhao, Weiqiang& Huang, Cheng C.& Otterson, Gregory A.& Leon, Marino E.& Tang, Yan& Shilo, Konstantin…[et al.]. 2012. Altered p16INK4 and RB1 Expressions Are Associated with Poor Prognosis in Patients with Nonsmall Cell Lung Cancer. Journal of Oncology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-511347
Modern Language Association (MLA)
Zhao, Weiqiang…[et al.]. Altered p16INK4 and RB1 Expressions Are Associated with Poor Prognosis in Patients with Nonsmall Cell Lung Cancer. Journal of Oncology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-511347
American Medical Association (AMA)
Zhao, Weiqiang& Huang, Cheng C.& Otterson, Gregory A.& Leon, Marino E.& Tang, Yan& Shilo, Konstantin…[et al.]. Altered p16INK4 and RB1 Expressions Are Associated with Poor Prognosis in Patients with Nonsmall Cell Lung Cancer. Journal of Oncology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-511347
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511347