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Associations between Intake of Folate, Methionine, and Vitamins B-12, B-6 and Prostate Cancer Risk in American Veterans
Joint Authors
Gerber, Leah
Williams, Christina D.
Hoyo, Cathrine
Grant, Delores J.
Vidal, Adriana C.
Chi, Jen-Tsan
Gaines, Alexis
Freedland, Stephen J.
Masko, Elizabeth
Shuler, Kathryn
Allott, Emma H.
McPhail, Megan
Calloway, Elizabeth
Source
Journal of Cancer Epidemiology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-09
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Prostate cancer (PC) is the second leading cause of cancer death in men.
Recent reports suggest that excess of nutrients involved in the one-carbon metabolism pathway increases PC risk; however, empirical data are lacking.
Veteran American men (272 controls and 144 PC cases) who attended the Durham Veteran American Medical Center between 2004–2009 were enrolled into a case-control study.
Intake of folate, vitamin B12, B6, and methionine were measured using a food frequency questionnaire.
Regression models were used to evaluate the association among one-carbon cycle nutrients, MTHFR genetic variants, and prostate cancer.
Higher dietary methionine intake was associated with PC risk (OR = 2.1; 95%CI 1.1–3.9) The risk was most pronounced in men with Gleason sum <7 (OR = 2.75; 95%CI 1.32– 5.73).
The association of higher methionine intake and PC risk was only apparent in men who carried at least one MTHFR A1298C allele (OR =6.7; 95%CI = 1.6–27.8), compared to MTHFR A1298A noncarrier men (OR =0.9; 95%CI = 0.24–3.92) (p-interaction =0.045).
There was no evidence for associations between B vitamins (folate, B12, and B6) and PC risk.
Our results suggest that carrying the MTHFR A1298C variants modifies the association between high methionine intake and PC risk.
Larger studies are required to validate these findings.
American Psychological Association (APA)
Vidal, Adriana C.& Grant, Delores J.& Williams, Christina D.& Masko, Elizabeth& Allott, Emma H.& Shuler, Kathryn…[et al.]. 2012. Associations between Intake of Folate, Methionine, and Vitamins B-12, B-6 and Prostate Cancer Risk in American Veterans. Journal of Cancer Epidemiology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-511353
Modern Language Association (MLA)
Vidal, Adriana C.…[et al.]. Associations between Intake of Folate, Methionine, and Vitamins B-12, B-6 and Prostate Cancer Risk in American Veterans. Journal of Cancer Epidemiology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-511353
American Medical Association (AMA)
Vidal, Adriana C.& Grant, Delores J.& Williams, Christina D.& Masko, Elizabeth& Allott, Emma H.& Shuler, Kathryn…[et al.]. Associations between Intake of Folate, Methionine, and Vitamins B-12, B-6 and Prostate Cancer Risk in American Veterans. Journal of Cancer Epidemiology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-511353
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511353