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Obstetrical Complications and Outcome in Two Families with Hereditary Angioedema due to Mutation in the F12 Gene
Joint Authors
Frémeaux-Bacchi, Véronique
Boyer-Neumann, Catherine
Picone, Olivier
Brivet, François G.
Donnadieu, Anne-Claire
Frydman, René
Source
Obstetrics and Gynecology International
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-13
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Backgroud.
Hereditary angioedema (HAE) is characterized by recurrent swelling of the skin, the abdomen (causing severe acute pain), and the airways.
A recently discovered type caused by mutations in the factor XII gene (designated as HAE type III) occurs mainly in women.
Estrogens may play an important role, but few obstetrical complications have been reported.
Case.
We report the symptoms and obstetrical complications of women in two families with HAE attributable to the p.
Thr328Lys mutation in the F12 gene.
Clinical manifestations included acute and severe maternal abdominal pain, with transient ascites, laryngeal edema, and fetal and neonatal deaths.
Patients had normal C4 levels and a normal C1 inhibitor gene.
Administration of C1-inhibitor concentration twice monthly decreased the attack rate in one mother, and its predelivery administration (1000 U) led to the delivery of healthy girls.
Conclusions.
Obstetricians and anesthesiologists should be aware of this rare cause of unexplained maternal ascites and in utero or fetal death associated with edema.
American Psychological Association (APA)
Picone, Olivier& Donnadieu, Anne-Claire& Brivet, François G.& Boyer-Neumann, Catherine& Frémeaux-Bacchi, Véronique& Frydman, René. 2010. Obstetrical Complications and Outcome in Two Families with Hereditary Angioedema due to Mutation in the F12 Gene. Obstetrics and Gynecology International،Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-511363
Modern Language Association (MLA)
Picone, Olivier…[et al.]. Obstetrical Complications and Outcome in Two Families with Hereditary Angioedema due to Mutation in the F12 Gene. Obstetrics and Gynecology International No. 2010 (2010), pp.1-5.
https://search.emarefa.net/detail/BIM-511363
American Medical Association (AMA)
Picone, Olivier& Donnadieu, Anne-Claire& Brivet, François G.& Boyer-Neumann, Catherine& Frémeaux-Bacchi, Véronique& Frydman, René. Obstetrical Complications and Outcome in Two Families with Hereditary Angioedema due to Mutation in the F12 Gene. Obstetrics and Gynecology International. 2010. Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-511363
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511363