Thymoglobulin Induction Dosing Strategies in a Low-Risk Kidney Transplant Population : Three or Four Days?
Joint Authors
Hardinger, Karen L.
Rasu, Rafia S.
Brennan, Daniel C.
Miller, Brent W.
Skelton, Rebecca
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-11-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The optimal dose and duration of rabbit antithymocyte globulin (rATG) induction has not been defined.
Methods.
We compared the safety and efficacy of 2 dosing strategies, rATG 1.5 mg/kg for 4 days (n=59) versus 2 mg/kg for 3 days (n=59), in a retrospective, cohort study.
Results.
Two-year rejection-free survival was 95% in each group (P=.983).
Renal function and infection rates were similar.
The incidence of leucopenia was similar, although the 2 mg/kg group was more likely to be thrombocytopenic on day 2 (4% versus 28%, P=.04).
Length of stay tended to be longer for the 1.5 mg/kg group (6.0±3.7 versus 5.1±1.9 days P=.104).
A cost savings of $920 per patient for rATG were seen in the 2 mg/kg group (P=.122).
Conclusions.
Shorter, more intense dosing of rATG is safe and effective.
The 3-day dose strategy resulted in a clinically shorter length of stay and may result in cost savings.
American Psychological Association (APA)
Hardinger, Karen L.& Rasu, Rafia S.& Skelton, Rebecca& Miller, Brent W.& Brennan, Daniel C.. 2010. Thymoglobulin Induction Dosing Strategies in a Low-Risk Kidney Transplant Population : Three or Four Days?. Journal of Transplantation،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-511366
Modern Language Association (MLA)
Hardinger, Karen L.…[et al.]. Thymoglobulin Induction Dosing Strategies in a Low-Risk Kidney Transplant Population : Three or Four Days?. Journal of Transplantation No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-511366
American Medical Association (AMA)
Hardinger, Karen L.& Rasu, Rafia S.& Skelton, Rebecca& Miller, Brent W.& Brennan, Daniel C.. Thymoglobulin Induction Dosing Strategies in a Low-Risk Kidney Transplant Population : Three or Four Days?. Journal of Transplantation. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-511366
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511366