Identification and Characterization of MicroRNAs in Macaca fascicularis by EST Analysis

Joint Authors

Zhu, Lin
Li, Donghai
Zhang, Haiyang
Zhang, Chenyu
Yang, Hao

Source

Comparative and Functional Genomics

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2012-07-05

Country of Publication

Egypt

No. of Pages

9

Main Subjects

Biology

Abstract EN

MicroRNAs (miRNAs) are small noncoding RNAs which repress gene expression at the posttranscriptional level.

In this study, an expressed sequence tag (EST)-based combined method was applied for the detection of miRNAs in Macaca fascicularis which is used as a model animal extensively in medical experiments, particularly those involved with neuroscience and disease.

Initially, previously known miRNA sequences from metazoans were used to blast with the EST databases of Macaca fascicularis, and then a range of filtering criteria was conducted to remove some pseudo ones.

At last a total of 8 novel conserved miRNAs were identified; their functions were further predicted and analyzed.

Together, our study provides insight into miRNAs and their functions in Macaca fascicularis, indicating that the EST analysis is an efficient and affordable alternative approach for identifying novel miRNA candidates.

American Psychological Association (APA)

Yang, Hao& Zhang, Haiyang& Zhu, Lin& Zhang, Chenyu& Li, Donghai. 2012. Identification and Characterization of MicroRNAs in Macaca fascicularis by EST Analysis. Comparative and Functional Genomics،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-511372

Modern Language Association (MLA)

Yang, Hao…[et al.]. Identification and Characterization of MicroRNAs in Macaca fascicularis by EST Analysis. Comparative and Functional Genomics No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-511372

American Medical Association (AMA)

Yang, Hao& Zhang, Haiyang& Zhu, Lin& Zhang, Chenyu& Li, Donghai. Identification and Characterization of MicroRNAs in Macaca fascicularis by EST Analysis. Comparative and Functional Genomics. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-511372

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-511372