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Early Pathologic Findings of Bronchiolitis Obliterans after Allogeneic Hematopoietic Stem Cell Transplantation : A Proposal from a Case
Joint Authors
Nishikii, Hidekazu
Kurita, Naoki
Yamada, Kenji
Suzukawa, Kazumi
Chiba, Shigeru
Obara, Naoshi
Hasegawa, Yuichi
Yokoyama, Yasuhisa
Ito, Masafumi
Nakamoto-Matsubara, Rie
Sakata-Yanagimoto, Mamiko
Okoshi, Yasushi
Noguchi, Masayuki
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-22
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Bronchiolitis obliterans (BO) is one of the serious, noninfectious pulmonary complications after allogeneic hematopoietic stem cell transplantation (allo-HSCT).
Early diagnosis of BO is usually difficult because patients are often asymptomatic at an initial stage of the disease and pathologic findings are available mostly at the late stages.
Therefore, the diagnosis of the disease is based on the pulmonary function test using the National Institute of Health consensus criteria.
Here, we report a case of slowly progressive BO.
A biopsy specimen at an early stage demonstrated alveolar destruction with lymphocyte infiltration in bronchial walls and mild narrowing of bronchioles without fibrosis, those were strongly indicative of initial pathologic changes of BO.
Definitive BO followed, which was proven by both clinical course and autopsy.
While alloreactive lymphocytes associated with chronic graft-versus-host disease are believed to initiate BO, we present a rare case that directly implies such a scenario.
American Psychological Association (APA)
Nakamoto-Matsubara, Rie& Nishikii, Hidekazu& Yamada, Kenji& Ito, Masafumi& Hasegawa, Yuichi& Kurita, Naoki…[et al.]. 2012. Early Pathologic Findings of Bronchiolitis Obliterans after Allogeneic Hematopoietic Stem Cell Transplantation : A Proposal from a Case. Case Reports in Hematology،Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-511373
Modern Language Association (MLA)
Nakamoto-Matsubara, Rie…[et al.]. Early Pathologic Findings of Bronchiolitis Obliterans after Allogeneic Hematopoietic Stem Cell Transplantation : A Proposal from a Case. Case Reports in Hematology No. 2012 (2012), pp.1-3.
https://search.emarefa.net/detail/BIM-511373
American Medical Association (AMA)
Nakamoto-Matsubara, Rie& Nishikii, Hidekazu& Yamada, Kenji& Ito, Masafumi& Hasegawa, Yuichi& Kurita, Naoki…[et al.]. Early Pathologic Findings of Bronchiolitis Obliterans after Allogeneic Hematopoietic Stem Cell Transplantation : A Proposal from a Case. Case Reports in Hematology. 2012. Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-511373
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511373