Cardiac Autonomic Function Correlates with Arterial Stiffness in the Early Stage of Type 1 Diabetes
Joint Authors
Makrilakis, K.
Liatis, Stavros
Tsiakou, A.
Alexiadou, K.
Katsilambros, Nicholas L.
Tentolouris, Nicholas
Source
Experimental Diabetes Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-24
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Arterial stiffness is increased in type 1 diabetes (T1D), before any clinical complications of the disease are evident.
The aim of the present paper was to investigate the association between cardiac autonomic function and arterial stiffness in a cohort of young T1D patients, without history of hypertension and any evidence of macrovascular and/or renal disease.
Large artery stiffness was assessed by measurement of carotid-femoral pulse wave velocity (PWV).
Cardiac autonomic function was assessed by the cardiovascular tests proposed by Ewing and Clarke.
Patients with a high cardiac autonomic neuropathy score (≥4) had significantly higher PWV than those with a low score (0-1).
A negative, heart rate-independent, correlation between PWV and heart rate variation during respiration was observed (r=−0.533, P<0.001).
In multivariable analysis, E/I index was the strongest correlate of PWV (β-coefficient = −0.326, P=0.002).
Cardiac parasympathetic function is a strong predictor of large arterial stiffness, in young T1D patients free of macrovascular and renal complications.
American Psychological Association (APA)
Liatis, Stavros& Alexiadou, K.& Tsiakou, A.& Makrilakis, K.& Katsilambros, Nicholas L.& Tentolouris, Nicholas. 2011. Cardiac Autonomic Function Correlates with Arterial Stiffness in the Early Stage of Type 1 Diabetes. Experimental Diabetes Research،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-511393
Modern Language Association (MLA)
Liatis, Stavros…[et al.]. Cardiac Autonomic Function Correlates with Arterial Stiffness in the Early Stage of Type 1 Diabetes. Experimental Diabetes Research No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-511393
American Medical Association (AMA)
Liatis, Stavros& Alexiadou, K.& Tsiakou, A.& Makrilakis, K.& Katsilambros, Nicholas L.& Tentolouris, Nicholas. Cardiac Autonomic Function Correlates with Arterial Stiffness in the Early Stage of Type 1 Diabetes. Experimental Diabetes Research. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-511393
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511393