Camptothecin-Based Regimens for Treatment of Ewing Sarcoma : sPast Studies and Future Directions
Author
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-06
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
New therapies are needed to improve survival for patients with Ewing sarcoma.
Over the past decade, camptothecin agents such as topotecan and irinotecan have demonstrated activity against Ewing sarcoma, especially in combination with alkylating agents.
Previous studies have shown camptothecin-based combinations to be tolerable outpatient strategies that are attractive for salvage therapy.
This paper highlights important issues related to drug dosing, schedule of administration, pharmacokinetics, toxicity, and activity of commonly used camptothecin-based regimens.
Also discussed are strategies for incorporating these regimens into therapy for newly diagnosed patients, including several potential possibilities for combination with targeted agents.
American Psychological Association (APA)
Wagner, Lars M.. 2011. Camptothecin-Based Regimens for Treatment of Ewing Sarcoma : sPast Studies and Future Directions. Sarcoma،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-511398
Modern Language Association (MLA)
Wagner, Lars M.. Camptothecin-Based Regimens for Treatment of Ewing Sarcoma : sPast Studies and Future Directions. Sarcoma No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-511398
American Medical Association (AMA)
Wagner, Lars M.. Camptothecin-Based Regimens for Treatment of Ewing Sarcoma : sPast Studies and Future Directions. Sarcoma. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-511398
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511398