![](/images/graphics-bg.png)
Antitumor Effect of Periplocin in TRAIL-Resistant Human Hepatocellular Carcinoma Cells through Downregulation of IAPs
Joint Authors
Lin, Li-Tsen
Ko, Ching-Huai
Kuo, Zong-Keng
Cheng, Chieh-Fang
Sun, Chung-Yuan
Tseng, Hsiang-Wen
Lu, I-Huang
Pan, I-Horng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-01
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Cortex periplocae is the dried root bark of Periploca sepium Bge., a traditional Chinese herb medicine.
It contains high amounts of cardiac glycosides.
Several cardiac glycosides have been reported to inhibit tumor growth or induce tumor cell apoptosis.
We extracted and purified cortex periplocae and identified periplocin as the active ingredient that inhibited the growth of TNF-related apoptosis-inducing ligand-(TRAIL-) resistant hepatocellular carcinoma cells.
The antitumor activity of periplocin was further increased by TRAIL cotreatment.
Periplocin sensitized TRAIL-resistant HCC through the following two mechanisms.
First, periplocin induced the expression of DR4 and FADD.
Second, the cotreatment of TRAIL and periplocin suppressed several inhibitors of apoptosis (IAPs).
Both mechanisms resulted in the activation of caspase 3, 8, and 9 and led to cell apoptosis.
In addition, intraperitoneal injection (IP) of periplocin repressed the growth of hepatocellular carcinoma (HCC) in xenograft tumor model in mice.
In summary, periplocin sensitized TRAIL-resistant HCC cells to TRAIL treatment and resulted in tumor cell apoptosis and the repression of tumor growth in vivo.
American Psychological Association (APA)
Cheng, Chieh-Fang& Lu, I-Huang& Tseng, Hsiang-Wen& Sun, Chung-Yuan& Lin, Li-Tsen& Kuo, Zong-Keng…[et al.]. 2013. Antitumor Effect of Periplocin in TRAIL-Resistant Human Hepatocellular Carcinoma Cells through Downregulation of IAPs. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-511399
Modern Language Association (MLA)
Cheng, Chieh-Fang…[et al.]. Antitumor Effect of Periplocin in TRAIL-Resistant Human Hepatocellular Carcinoma Cells through Downregulation of IAPs. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-511399
American Medical Association (AMA)
Cheng, Chieh-Fang& Lu, I-Huang& Tseng, Hsiang-Wen& Sun, Chung-Yuan& Lin, Li-Tsen& Kuo, Zong-Keng…[et al.]. Antitumor Effect of Periplocin in TRAIL-Resistant Human Hepatocellular Carcinoma Cells through Downregulation of IAPs. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-511399
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511399