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Changes in the Expression of Vascular Endothelial Growth Factor after Fetal Tracheal Occlusion in an Experimental Model of Congenital Diaphragmatic Hernia
Joint Authors
Muñoz, M. A.
Maderuelo, E.
Sanz-López, E.
Chimenti, P.
Sánchez Luna, Manuel
Lorente, R.
Peláez, D.
Source
Critical Care Research and Practice
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-27
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Introduction.
Vascular endothelial growth factor (VEGF), an angiogenic factor secreted by type II pneumocytes, could play a role in congenital diaphragmatic hernia (CDH) pathogenesis.
Animal studies suggest that VEGF accelerates lung growth.
Aim.
To quantify VEGF on fetal lungs in a nitrofen rat model for CDH and to analyze the effect of tracheal occlusion (TO) in VEGF in fetal lung rats after nitrofen and in control rats not exposed to nitrofen.
Methods.
Pregnant rats received nitrofen on day 9.5 of gestation.
Fetuses were divided into 2 groups: those that underwent TO on day 20 and those that did not.
On day 21, fetuses were delivered, and the lungs were dissected for subsequent VEGF quantification.
Results.
CDH was detected in 43% of the fetuses that received nitrofen.
Fetuses with CDH showed significantly reduced lung weight/fetal weight ratio and lower VEGF levels than the remainder.
A higher VEGF value was observed after TO.
Conclusions.
VEGF protein was significantly lower in fetuses with CDH.
TO induced a significant increase in VEGF compared to the fetuses that did not undergo TO.
Although not statistically significant, we observed higher VEGF levels in fetuses with CDH and TO compared to fetuses with CDH and no further intervention.
American Psychological Association (APA)
Sanz-López, E.& Maderuelo, E.& Peláez, D.& Chimenti, P.& Lorente, R.& Muñoz, M. A.…[et al.]. 2013. Changes in the Expression of Vascular Endothelial Growth Factor after Fetal Tracheal Occlusion in an Experimental Model of Congenital Diaphragmatic Hernia. Critical Care Research and Practice،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-511404
Modern Language Association (MLA)
Sanz-López, E.…[et al.]. Changes in the Expression of Vascular Endothelial Growth Factor after Fetal Tracheal Occlusion in an Experimental Model of Congenital Diaphragmatic Hernia. Critical Care Research and Practice No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-511404
American Medical Association (AMA)
Sanz-López, E.& Maderuelo, E.& Peláez, D.& Chimenti, P.& Lorente, R.& Muñoz, M. A.…[et al.]. Changes in the Expression of Vascular Endothelial Growth Factor after Fetal Tracheal Occlusion in an Experimental Model of Congenital Diaphragmatic Hernia. Critical Care Research and Practice. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-511404
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511404