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Increasing the Radioiodine Dose Does Not Improve Cure Rates in Severe Graves' Hyperthyroidism : A Clinical Trial with Historical Control
Joint Authors
Andrade, Vânia A.
Escouto Machado, Walter
Dora, Jose Miguel
Scheffel, Rafael Selbach
Maia, Ana Luiza
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-31
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objective.
It is generally accepted that higher doses of radioiodine (131I) improve cure rates in Graves’ disease (GD).
In this trial we sought to evaluate whether very high 131I doses increase the efficacy of treatment in severe GD.
Design.
Clinical trial with historical control.
Patients with GD and a goiter ≥48 mL were eligible for the study.
The patients in the contemporaneous intervention cohort were treated with 250 μCi of 131I/mL thyroid tissue, corrected by 24-RAIU values (Group 1; n=15).
A subgroup of patients with GD and a goiter ≥48 mL who were treated with 200 μCi of 131I/mL/24-RAIU in a previously published randomized controlled trial served as a historical control group (Group 2; n=15).
The primary outcome evaluated was the one-year cure rate.
Results.
There were no significant baseline differences regarding age, gender, body mass index, smoking status, pretreatment with methimazole, thyroid volume, or thyroid hormone levels of the two treatment groups.
The cumulative 12-month cure rate for the patients in Group 1 was 66.6%, a figure similar to the 12-month cure rate observed in Group 2 (60.0%; P=0.99).
Conclusions.
Our results suggest that increasing the 131I dose does not improve cure rates in severe GD.
This trial is registered with ClinicalTrials.gov NCT01039818.
American Psychological Association (APA)
Dora, Jose Miguel& Escouto Machado, Walter& Andrade, Vânia A.& Scheffel, Rafael Selbach& Maia, Ana Luiza. 2013. Increasing the Radioiodine Dose Does Not Improve Cure Rates in Severe Graves' Hyperthyroidism : A Clinical Trial with Historical Control. Journal of Thyroid Research،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-511426
Modern Language Association (MLA)
Dora, Jose Miguel…[et al.]. Increasing the Radioiodine Dose Does Not Improve Cure Rates in Severe Graves' Hyperthyroidism : A Clinical Trial with Historical Control. Journal of Thyroid Research No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-511426
American Medical Association (AMA)
Dora, Jose Miguel& Escouto Machado, Walter& Andrade, Vânia A.& Scheffel, Rafael Selbach& Maia, Ana Luiza. Increasing the Radioiodine Dose Does Not Improve Cure Rates in Severe Graves' Hyperthyroidism : A Clinical Trial with Historical Control. Journal of Thyroid Research. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-511426
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511426