The Effects of Interleukin-1β in Tumor Necrosis Factor-α-Induced Acute Pulmonary Inflammation in Mice
Joint Authors
Saperstein, Sara
Huyck, Heidie
Pryhuber, Gloria
Johnston, Carl
Finkelstein, Jacob
Kimball, Elizabeth
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-11-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
We determined the role of interleukin-1β (IL-1β) signaling on tumor necrosis factor alpha-induced (TNF-α) lung neutrophil influx as well as neutrophil chemoattractant macrophage inflammatory protein (MIP-2) and KC and soluble TNF-α receptor (TNFR) levels utilizing wildtype (WT), TNF receptor double knockout (TNFR1/TNFR2 KO), and IL-1β KO mice after oropharyngeal instillation with TNF-α.
A significant increase in neutrophil accumulation in bronchoalveolar lavage fluid (BALF) and lung interstitium was detected in the WT mice six hours after TNF-α exposure.
This correlated with an increase in BALF MIP-2.
In contrast, BALF neutrophil numbers were not increased by TNF-α treatment of IL-1β KOs, correlating with a failure to induce BALF MIP-2 and a trend toward increased BALF soluble TNFR1.
TNF-α-instillation increased lavage and serum KC and soluble TNFR2 irrespective of IL-1β expression.
These results suggest IL-1β contributes, in part, to TNF-α-mediated, chemokine release, and neutrophil recruitment to the lung, potentially associated with altered soluble TNFR1 release into the BALF.
American Psychological Association (APA)
Saperstein, Sara& Huyck, Heidie& Kimball, Elizabeth& Johnston, Carl& Finkelstein, Jacob& Pryhuber, Gloria. 2009. The Effects of Interleukin-1β in Tumor Necrosis Factor-α-Induced Acute Pulmonary Inflammation in Mice. Mediators of Inflammation،Vol. 2009, no. 2009, pp.1-10.
https://search.emarefa.net/detail/BIM-511460
Modern Language Association (MLA)
Saperstein, Sara…[et al.]. The Effects of Interleukin-1β in Tumor Necrosis Factor-α-Induced Acute Pulmonary Inflammation in Mice. Mediators of Inflammation No. 2009 (2009), pp.1-10.
https://search.emarefa.net/detail/BIM-511460
American Medical Association (AMA)
Saperstein, Sara& Huyck, Heidie& Kimball, Elizabeth& Johnston, Carl& Finkelstein, Jacob& Pryhuber, Gloria. The Effects of Interleukin-1β in Tumor Necrosis Factor-α-Induced Acute Pulmonary Inflammation in Mice. Mediators of Inflammation. 2009. Vol. 2009, no. 2009, pp.1-10.
https://search.emarefa.net/detail/BIM-511460
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511460