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Watch the GAP : Emerging Roles for IQ Motif-Containing GTPase-Activating Proteins IQGAPs in Hepatocellular Carcinoma
Author
Source
International Journal of Hepatology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
IQ motif-containing GTPase-activating proteins IQGAP1 and IQGAP2 are highly homologous multidomain scaffolding proteins.
Their major function consists of integration of Rho GTPase and Ca2+/calmodulin signals with cell adhesive and cytoskeletal reorganizational events.
Recent studies showed that they play an important role in carcinogenesis.
There is growing evidence that IQGAP2 is a novel tumor suppressor counteracting the effects of IQGAP1, an oncogene, in several cancers, especially in hepatocellular carcinoma (HCC).
While HCC is highly prevalent and one of the deadliest cancers worldwide, the signaling pathways involved are not fully understood and treatment of advanced disease still represents an area of high unmet medical need.
This paper compiles various findings from studies in mouse models, cell lines, and patient samples that support future development of IQGAPs into new therapeutic targets.
It also discusses distinct features of IQGAP2 in an attempt to provide insight into the mechanism of the seemingly paradoxical opposing roles of the two very similar IQGAP proteins in carcinogenesis.
American Psychological Association (APA)
Schmidt, Valentina A.. 2012. Watch the GAP : Emerging Roles for IQ Motif-Containing GTPase-Activating Proteins IQGAPs in Hepatocellular Carcinoma. International Journal of Hepatology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-511461
Modern Language Association (MLA)
Schmidt, Valentina A.. Watch the GAP : Emerging Roles for IQ Motif-Containing GTPase-Activating Proteins IQGAPs in Hepatocellular Carcinoma. International Journal of Hepatology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-511461
American Medical Association (AMA)
Schmidt, Valentina A.. Watch the GAP : Emerging Roles for IQ Motif-Containing GTPase-Activating Proteins IQGAPs in Hepatocellular Carcinoma. International Journal of Hepatology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-511461
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511461