Short Communication : Is Ethanol-Based Hand Sanitizer Involved in Acute Pancreatitis after Excessive Disinfection?—An Evaluation with the Use of PBPK Model
Joint Authors
Artigou, Catherine
Desmares, Catherine
Verdier, Cécile
Charest-Tardif, Ginette
Bodin, Laurent
Tardif, Robert
Sater, Nessryne
Huynh-Delerme, Céline
Ould-Elhkim, Mostafa
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Pharmacy, Health & Medical Sciences
Medicine
Abstract EN
An occupational physician reported to the French Health Products Safety Agency (Afssaps) a case of adverse effect of acute pancreatitis (AP) in a teaching nurse, after multiple demonstrations with ethanol-based hand sanitizers (EBHSs) used in a classroom with defective mechanical ventilation.
It was suggested by the occupational physician that the exposure to ethanol may have produced a significant blood ethanol concentration and subsequently the AP.
In order to verify if the confinement situation due to defective mechanical ventilation could increase the systemic exposure to ethanol via inhalation route, a physiologically based pharmacokinetic (PBPK) modeling was used to predict ethanol blood levels.
Under the worst case scenario, the simulation by PBPK modeling showed that the maximum blood ethanol concentration which can be predicted of 5.9 mg/l is of the same order of magnitude to endogenous ethanol concentration (mean = 1.1 mg/L; median = 0.4 mg/L; range = 0–35 mg/L) in nondrinker humans (Al-Awadhi et al., 2004).
The present study does not support the likelihood that EBHS leads to an increase in systemic ethanol concentration high enough to provoke an acute pancreatitis.
American Psychological Association (APA)
Huynh-Delerme, Céline& Artigou, Catherine& Bodin, Laurent& Tardif, Robert& Charest-Tardif, Ginette& Verdier, Cécile…[et al.]. 2012. Short Communication : Is Ethanol-Based Hand Sanitizer Involved in Acute Pancreatitis after Excessive Disinfection?—An Evaluation with the Use of PBPK Model. Journal of Toxicology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-511487
Modern Language Association (MLA)
Huynh-Delerme, Céline…[et al.]. Short Communication : Is Ethanol-Based Hand Sanitizer Involved in Acute Pancreatitis after Excessive Disinfection?—An Evaluation with the Use of PBPK Model. Journal of Toxicology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-511487
American Medical Association (AMA)
Huynh-Delerme, Céline& Artigou, Catherine& Bodin, Laurent& Tardif, Robert& Charest-Tardif, Ginette& Verdier, Cécile…[et al.]. Short Communication : Is Ethanol-Based Hand Sanitizer Involved in Acute Pancreatitis after Excessive Disinfection?—An Evaluation with the Use of PBPK Model. Journal of Toxicology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-511487
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511487