Raman Microimaging Using a Novel Multifiber-Based Device : A Feasibility Study on Pharmaceutical Tablets

Abstract EN

Raman microimaging is a potential analytical technique in health field and presents many possible pharmaceutical applications.

In this study, we tested a micrometer spatial resolution probe coupled to a portable Raman imager via an indexed multifiber bundle.

At the level of the probe, the fibers were arranged in a circular geometry in order to fit to the pupil of an objective.

The imaging potential of this Raman system was assessed on pharmaceutical-like pellets.

We showed that this setup permits to record, nearly in real time, Raman images with a micrometer resolution.

The collected images revealed a marked heterogeneity in chemicals distribution.

Further investigations will be led on cells and biological tissues to evaluate the potential of this Raman imaging device for biomedical applications.