Aberrant Hepatic Methionine Metabolism and Gene Methylation in the Pathogenesis and Treatment of Alcoholic Steatohepatitis
Joint Authors
Medici, Valentina
Halsted, Charles H.
Source
International Journal of Hepatology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-06
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The pathogenesis of alcoholic steatohepatitis (ASH) involves ethanol-induced aberrations in hepatic methionine metabolism that decrease levels of S-adenosylmethionine (SAM), a compound which regulates the synthesis of the antioxidant glutathione and is the principal methyl donor in the epigenetic regulation of genes relevant to liver injury.
The present paper describes the effects of ethanol on the hepatic methionine cycle, followed by evidence for the central role of reduced SAM in the pathogenesis of ASH according to clinical data and experiments in ethanol-fed animals and in cell models.
The efficacy of supplemental SAM in the prevention of ASH in animal models and in the clinical treatment of ASH will be discussed.
American Psychological Association (APA)
Halsted, Charles H.& Medici, Valentina. 2011. Aberrant Hepatic Methionine Metabolism and Gene Methylation in the Pathogenesis and Treatment of Alcoholic Steatohepatitis. International Journal of Hepatology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-511541
Modern Language Association (MLA)
Halsted, Charles H.& Medici, Valentina. Aberrant Hepatic Methionine Metabolism and Gene Methylation in the Pathogenesis and Treatment of Alcoholic Steatohepatitis. International Journal of Hepatology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-511541
American Medical Association (AMA)
Halsted, Charles H.& Medici, Valentina. Aberrant Hepatic Methionine Metabolism and Gene Methylation in the Pathogenesis and Treatment of Alcoholic Steatohepatitis. International Journal of Hepatology. 2011. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-511541
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511541