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Cavernous Hemangioma-Like Kaposi Sarcoma : Histomorphologic Features and Differential Diagnosis
Joint Authors
Gun, Banu Dogan
Solak Tekin, Nilgün
Onak Kandemir, Nilüfer
Barut, Figen
Oğuz Özdamar, Şükrü
Hallaç Keser, Sevinç
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-25
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Aim.
Cavernous hemangioma-like Kaposi sarcoma is a rare morphologic type of Kaposi sarcoma.
So far there are no cases in the literature defining the histological features of this morphologic spectrum in detail.
In this study we presented two classical-type cutaneous Kaposi sarcoma cases with histologic findings resembling cavernous hemangioma in company with clinical and histopathological data.
Cases.
One hundred and eighty-five classical-type cutaneous Kaposi sarcoma lesions in 79 patients were assessed retrospectively in terms of histopathological features.
Findings of two cases showing features of cavernous hemangioma-like Kaposi sarcoma whose clinical data could be accessed were presented in accompany with the literature data.
Both cases were detected to have bluish-purple, protruded, irregularly bordered cutaneous lesions.
Histopathological examination revealed a lesion formed by cavernous hemangioma-like vascular structures organized in a lobular pattern that became dilated and filled with blood.
Typical histological findings of early-stage KS, consisting of mononuclear inflammation, extravasated erythrocytes, and a few immature vascular structures in superficial dermis, were observed.
All cases were serologically HIV-1 negative.
A positive reaction with HHV-8, CD31, CD34, and D2-40 monoclonal antibodies was identified at both cavernous hemangioma-like areas and in immature vascular structures.
Results.
Cavernous hemangioma-like Kaposi sarcoma is a rare Kaposi sarcoma variant presenting with diagnostic challenges, that may be confused with hemangioma.
As characteristic morphological features may not be observed in every case, it is important for diagnostic purposes to show immunohistochemical HHV-8 positivity in this variant.
American Psychological Association (APA)
Onak Kandemir, Nilüfer& Barut, Figen& Gun, Banu Dogan& Solak Tekin, Nilgün& Hallaç Keser, Sevinç& Oğuz Özdamar, Şükrü. 2013. Cavernous Hemangioma-Like Kaposi Sarcoma : Histomorphologic Features and Differential Diagnosis. Case Reports in Medicine،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-511547
Modern Language Association (MLA)
Onak Kandemir, Nilüfer…[et al.]. Cavernous Hemangioma-Like Kaposi Sarcoma : Histomorphologic Features and Differential Diagnosis. Case Reports in Medicine No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-511547
American Medical Association (AMA)
Onak Kandemir, Nilüfer& Barut, Figen& Gun, Banu Dogan& Solak Tekin, Nilgün& Hallaç Keser, Sevinç& Oğuz Özdamar, Şükrü. Cavernous Hemangioma-Like Kaposi Sarcoma : Histomorphologic Features and Differential Diagnosis. Case Reports in Medicine. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-511547
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511547