The Laboratory of Genetics and Physiology 2 : Emerging Insights into the Controversial Functions of This RIG-I-Like Receptor
Joint Authors
Zhang, Xiangle
Zheng, Haixue
Wang, Guoqing
Zhu, Zixiang
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The laboratory of genetics and physiology 2 (LGP2) is a key component of the RNA helicase family of retinoic acid-inducible gene 1- (RIG-I-) like receptors (RLRs) and is widely involved in viral RNA recognition and regulation during innate immune responses.
Unlike RIG-I and melanoma differentiation-associated 5, both RLR members, LGP2 lacks the caspase-recruitment domain (CARD), which is required for recruiting and interacting with downstream signaling proteins to activate a cascade of downstream signaling events.
The absence of the CARD results in divergent functional performance for LGP2 compared to these other RLR members.
Both negative and positive regulatory roles have been reported for LGP2 in antiviral immune responses.
It is currently unclear how the unusual properties of LGP2 mediate opposing roles.
Future studies should elucidate the molecular mechanism(s) of LGP2 action.
This minireview provides a brief overview of LGP2 structure and functions, with an expanded discussion on the regulation mechanisms in response to viral infection, hopefully stimulating insight into the divergent roles of LGP2 in the regulation of antiviral immune responses.
American Psychological Association (APA)
Zhu, Zixiang& Zhang, Xiangle& Wang, Guoqing& Zheng, Haixue. 2014. The Laboratory of Genetics and Physiology 2 : Emerging Insights into the Controversial Functions of This RIG-I-Like Receptor. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-511567
Modern Language Association (MLA)
Zhu, Zixiang…[et al.]. The Laboratory of Genetics and Physiology 2 : Emerging Insights into the Controversial Functions of This RIG-I-Like Receptor. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-511567
American Medical Association (AMA)
Zhu, Zixiang& Zhang, Xiangle& Wang, Guoqing& Zheng, Haixue. The Laboratory of Genetics and Physiology 2 : Emerging Insights into the Controversial Functions of This RIG-I-Like Receptor. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-511567
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511567