![](/images/graphics-bg.png)
B Cell Responses to CpG Correlate with CXCL16 Expression Levels in Common Variable Immunodeficiency
Joint Authors
Badolato, Raffaele
Soresina, Annarosa
Baronio, Manuela
Plebani, Alessandro
Vitali, Massimiliano
Lougaris, Vassilios
Tampella, Giacomo
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Broad Toll-like receptor 9 (TLR9) signalling defects after CpG in vitro stimulation have been described in common variable immunodeficiency (CVID).
CXCL16, a surface receptor, was recently shown to influence cell responses to CpG.
We evaluated the expression and function of CXCL16 on B cells from healthy controls and CVID patients.
We report that CXCL16 is normally expressed on B cells throughout peripheral maturation.
Decreased B cell expression of CXCL16 was observed in a subgroup of CVID patients that correlated with defective in vitro responses to CpG (such as upregulation of CD69, CD86, AICDA, IL-6, and TLR9).
Our data suggest that expression levels of a surface receptor, namely, CXCL16, correlate with B cell responses mediated by TLR9 in common variable immunodeficiency.
American Psychological Association (APA)
Lougaris, Vassilios& Baronio, Manuela& Vitali, Massimiliano& Tampella, Giacomo& Soresina, Annarosa& Badolato, Raffaele…[et al.]. 2012. B Cell Responses to CpG Correlate with CXCL16 Expression Levels in Common Variable Immunodeficiency. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-511570
Modern Language Association (MLA)
Lougaris, Vassilios…[et al.]. B Cell Responses to CpG Correlate with CXCL16 Expression Levels in Common Variable Immunodeficiency. The Scientific World Journal No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-511570
American Medical Association (AMA)
Lougaris, Vassilios& Baronio, Manuela& Vitali, Massimiliano& Tampella, Giacomo& Soresina, Annarosa& Badolato, Raffaele…[et al.]. B Cell Responses to CpG Correlate with CXCL16 Expression Levels in Common Variable Immunodeficiency. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-511570
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511570